ID   OAF3_ZYGRC              Reviewed;         842 AA.
AC   C5DUX2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; OrderedLocusNames=ZYRO0D02090g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; CU928176; CAR27591.1; -; Genomic_DNA.
DR   RefSeq; XP_002496524.1; XM_002496479.1.
DR   AlphaFoldDB; C5DUX2; -.
DR   SMR; C5DUX2; -.
DR   STRING; 559307.C5DUX2; -.
DR   EnsemblFungi; CAR27591; CAR27591; ZYRO0D02090g.
DR   GeneID; 8203772; -.
DR   KEGG; zro:ZYRO0D02090g; -.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   InParanoid; C5DUX2; -.
DR   Proteomes; UP000008536; Chromosome D.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..842
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409046"
FT   DNA_BIND        22..50
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          55..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   842 AA;  98212 MW;  2895B8953D0FF920 CRC64;
     MVLSQDVRGA SVRRRNRPTV VCTNCKRRKS KCDRQNPCSN CVRFGNKDTC HYVQNPKNTE
     SQHGEDTDNK VKKQQPQMIK GKRNGTSSSI VGSKASSISP TGQSLDVPLV LSGKNYVNLS
     PSGNFVEFKR SAVTMFSYFC KRAIQDRDLY LKALVTFRSI AVEMTTNTLR GTKNYSKNPS
     LPESFKPLSI FDADGDPLSS DSLFRQHQLI HKSLFDKYGK YRKDEAIKIV DVCELLNDNL
     PSRSLFIDHI LVHFESHVIH MVPIFEMEFL KYDVNNFYDK WEQSREISVK DFDHMVCCVI
     LLITKICILS TKFARLPSEL LEHFEKLDTS KYIAIIHYYM FEMKSLRKCT LRQLQILLLL
     RFYHWCAPED GDGDSLQHSH ILMGTIIASC QEMGISWLCI RDPGIYWFQL FGQSKRVPFI
     LSPEDFKIIY QMIWSYVLHW DRKMFLINGQ ECLIGKSHLY DVTGQELSWH HRMVALDHII
     MKMNDILNDS PSRVDIVALK QEWNNALRIF ELIRDTKKEH LHLNFEYETT LELFRLCLSH
     AELTHLEQVN DVESFHLTVQ SLWDQIVKLA SKCHRYFYGP QEMDPYSRFF TNKIISVVAD
     KLCTLIPAFV LRLNRFGEMG FDQMNMMVKF LFGVCSMYYN ELGFDYYRCF ESMFTAKISY
     KILNRPRNKN PWEIILEFLL CQLEKEGIKD QLRELKIIQN LPVLVSLRES LNLIPEYHRD
     AVKLWNTDVV PIGHSSVNFT LNLREESLEP FLVDRYSQTF NIFTSFYDHA SSQLAEEAED
     TSSKIQYNVE NSAEQAQEIA ETNAVPVEHP LSLEPTNPVN LEESNLELIR NMFEPLDFIS
     FF