ID   OAF_HUMAN               Reviewed;         273 AA.
AC   Q86UD1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Out at first protein homolog;
DE   AltName: Full=HCV NS5A-transactivated protein 13 target protein 2;
DE   Flags: Precursor;
GN   Name=OAF; Synonyms=NS5ATP13TP2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Dang X., Cheng J., Deng H.;
RT   "Screening and cloning of the target genes transactivated by human gene 13
RT   transactivated by nonstructural protein 5A of hepatitis C virus using
RT   suppression subtractive hybridization technique.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the OAF family. {ECO:0000305}.
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DR   EMBL; AY459296; AAR23238.1; -; mRNA.
DR   EMBL; BC047726; AAH47726.1; -; mRNA.
DR   CCDS; CCDS8430.1; -.
DR   RefSeq; NP_848602.1; NM_178507.2.
DR   AlphaFoldDB; Q86UD1; -.
DR   BioGRID; 128640; 137.
DR   IntAct; Q86UD1; 18.
DR   STRING; 9606.ENSP00000332613; -.
DR   iPTMnet; Q86UD1; -.
DR   PhosphoSitePlus; Q86UD1; -.
DR   BioMuta; OAF; -.
DR   DMDM; 74727479; -.
DR   EPD; Q86UD1; -.
DR   jPOST; Q86UD1; -.
DR   MassIVE; Q86UD1; -.
DR   MaxQB; Q86UD1; -.
DR   PaxDb; Q86UD1; -.
DR   PeptideAtlas; Q86UD1; -.
DR   PRIDE; Q86UD1; -.
DR   ProteomicsDB; 69800; -.
DR   Antibodypedia; 49399; 83 antibodies from 21 providers.
DR   DNASU; 220323; -.
DR   Ensembl; ENST00000328965.9; ENSP00000332613.3; ENSG00000184232.9.
DR   GeneID; 220323; -.
DR   KEGG; hsa:220323; -.
DR   MANE-Select; ENST00000328965.9; ENSP00000332613.3; NM_178507.4; NP_848602.1.
DR   UCSC; uc001pxb.4; human.
DR   CTD; 220323; -.
DR   DisGeNET; 220323; -.
DR   GeneCards; OAF; -.
DR   HGNC; HGNC:28752; OAF.
DR   HPA; ENSG00000184232; Tissue enriched (liver).
DR   neXtProt; NX_Q86UD1; -.
DR   OpenTargets; ENSG00000184232; -.
DR   PharmGKB; PA142671234; -.
DR   VEuPathDB; HostDB:ENSG00000184232; -.
DR   eggNOG; ENOG502QWDA; Eukaryota.
DR   GeneTree; ENSGT00390000012008; -.
DR   HOGENOM; CLU_043995_1_0_1; -.
DR   InParanoid; Q86UD1; -.
DR   OMA; CFITRLH; -.
DR   OrthoDB; 1311469at2759; -.
DR   PhylomeDB; Q86UD1; -.
DR   TreeFam; TF323953; -.
DR   PathwayCommons; Q86UD1; -.
DR   SignaLink; Q86UD1; -.
DR   BioGRID-ORCS; 220323; 9 hits in 1074 CRISPR screens.
DR   ChiTaRS; OAF; human.
DR   GenomeRNAi; 220323; -.
DR   Pharos; Q86UD1; Tbio.
DR   PRO; PR:Q86UD1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q86UD1; protein.
DR   Bgee; ENSG00000184232; Expressed in right lobe of liver and 174 other tissues.
DR   ExpressionAtlas; Q86UD1; baseline and differential.
DR   Genevisible; Q86UD1; HS.
DR   InterPro; IPR026315; Oaf.
DR   PANTHER; PTHR13423; PTHR13423; 1.
DR   Pfam; PF14941; OAF; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..273
FT                   /note="Out at first protein homolog"
FT                   /id="PRO_0000292427"
FT   VARIANT         210
FT                   /note="H -> R (in dbSNP:rs2508489)"
FT                   /id="VAR_032993"
FT   VARIANT         217
FT                   /note="R -> H (in dbSNP:rs2508490)"
FT                   /id="VAR_032994"
SQ   SEQUENCE   273 AA;  30688 MW;  EC752B522917F496 CRC64;
     MRLPGVPLAR PALLLLLPLL APLLGTGAPA ELRVRVRLPD GQVTEESLQA DSDADSISLE
     LRKPDGTLVS FTADFKKDVK VFRALILGEL EKGQSQFQAL CFVTQLQHNE IIPSEAMAKL
     RQKNPRAVRQ AEEVRGLEHL HMDVAVNFSQ GALLSPHLHN VCAEAVDAIY TRQEDVRFWL
     EQGVDSSVFE ALPKASEQAE LPRCRQVGDH GKPCVCRYGL SLAWYPCMLK YCHSRDRPTP
     YKCGIRSCQK SYSFDFYVPQ RQLCLWDEDP YPG