ID   OAPA_HAEIN              Reviewed;         431 AA.
AC   P44415;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Opacity-associated protein OapA;
GN   Name=oapA; OrderedLocusNames=HI_0330;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Rd / H175;
RX   PubMed=8559074; DOI=10.1111/j.1365-2958.1995.mmi_17030555.x;
RA   Weiser J.N., Chong S.T., Greenberg D., Fong W.;
RT   "Identification and characterization of a cell envelope protein of
RT   Haemophilus influenzae contributing to phase variation in colony opacity
RT   and nasopharyngeal colonization.";
RL   Mol. Microbiol. 17:555-564(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Cell envelope protein involved in phase variation, confers
CC       opaque colony phenotype. {ECO:0000269|PubMed:8559074}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8559074}.
CC   -!- INDUCTION: Undergoes phase variation. {ECO:0000269|PubMed:8559074}.
CC   -!- DISRUPTION PHENOTYPE: Loss of the ability to colonize the nasopharynx
CC       of infant rats. {ECO:0000269|PubMed:8559074}.
CC   -!- SIMILARITY: Belongs to the OapA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U17037; AAA56761.1; -; Genomic_DNA.
DR   EMBL; L42023; AAC21992.1; -; Genomic_DNA.
DR   PIR; A64062; A64062.
DR   RefSeq; NP_438494.1; NC_000907.1.
DR   RefSeq; WP_005694343.1; NC_000907.1.
DR   AlphaFoldDB; P44415; -.
DR   SMR; P44415; -.
DR   STRING; 71421.HI_0330; -.
DR   EnsemblBacteria; AAC21992; AAC21992; HI_0330.
DR   KEGG; hin:HI_0330; -.
DR   PATRIC; fig|71421.8.peg.347; -.
DR   eggNOG; COG3061; Bacteria.
DR   eggNOG; COG3266; Bacteria.
DR   HOGENOM; CLU_602387_0_0_6; -.
DR   OMA; TQENDPL; -.
DR   BioCyc; HINF71421:G1GJ1-346-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0042834; F:peptidoglycan binding; IEA:InterPro.
DR   GO; GO:0000920; P:septum digestion after cytokinesis; IBA:GO_Central.
DR   InterPro; IPR013731; OapA_N.
DR   InterPro; IPR007340; Opacity-associatedA.
DR   Pfam; PF04225; OapA; 1.
DR   Pfam; PF08525; OapA_N; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..431
FT                   /note="Opacity-associated protein OapA"
FT                   /id="PRO_0000058016"
FT   REGION          1..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  47009 MW;  E80EF3358DB63179 CRC64;
     MNSMDKNQQS SQNELDLGLN QEPITPKKTI QPSSSILGKA KGLFAKKNHV QTNFQQRKEP
     TFGDSSTQEN DPLIPSENLK KVQKPVLQTS STEENISAVD EEISAENNAD EPVEKAEKPI
     LAQPEKWKIL QVLPAKHRRL FMAIFVLVIL LIIFFALKPS SDTVESFTQS NSNEVPVQFQ
     SLDQSQPLET TILDNPPAQN QMAVEQANQS EFAPKAEEAA NNTTAQNPLV ENAPMQQNVV
     QSPSQMPNEM AAASVAPMQP AQAEQPKATV PVQPMKKAVE PQVAHKDTVK KEVKVAEKAQ
     APAKATEQNV AKTAGNAPIV EAKPVQAKKE KKVQIVDAKP VSKSTASRLS AKTLTVPKGV
     SLMQLFRDNQ LNISDVNAMS KATGAGNVLS SFKSGDKVTV SVNNQGRVNE MRLSNGARFV
     RQSDGSYQYK K