ID   OAR1_LOCMI              Reviewed;         484 AA.
AC   Q25321;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Tyramine receptor 1;
DE   AltName: Full=Tyr-Loc1;
GN   Name=GCR1;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   TISSUE=Neuron;
RX   PubMed=7760020; DOI=10.1046/j.1471-4159.1995.64062387.x;
RA   Vanden Broeck J.J.M., Vulsteke V., Huybrechts R., de Loof A.;
RT   "Characterization of a cloned locust tyramine receptor cDNA by functional
RT   expression in permanently transformed Drosophila S2 cells.";
RL   J. Neurochem. 64:2387-2395(1995).
CC   -!- FUNCTION: G-protein coupled receptor for tyramine, a known
CC       neurotransmitter and neuromodulator and direct precursor of octopamine.
CC       The rank order of potency for agonists of this receptor is tyramine >
CC       naphazoline > tolazoline > DL-octopamine > dopamine > epinephrine > 5-
CC       hydroxytryptamine. For antagonists, the rank order is yohimbine >
CC       chlorpromazine > mianserin > phentolamine > metoclopramide.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Present mainly in the central nervous system,
CC       especially in the supra- and subesophageal, thoracic and abdominal
CC       ganglia. Not found in the distal part of optic lobes.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the nervous system by the first
CC       larval stage.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X69520; CAA49268.1; -; mRNA.
DR   PIR; S58868; S58868.
DR   AlphaFoldDB; Q25321; -.
DR   SMR; Q25321; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004989; F:octopamine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002002; Octopmn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00664; OCTOPAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..484
FT                   /note="Tyramine receptor 1"
FT                   /id="PRO_0000069954"
FT   TOPO_DOM        1..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..109
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..126
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..411
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..433
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        434..448
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..470
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        471..484
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          253..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        13
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   484 AA;  53531 MW;  4484FBC85A810619 CRC64;
     MVRVELQAAS LMNGSSAAEE PQDALVGGDA CGGRRPPSVL GVRLAVPEWE VAVTAVSLSL
     IILITIVGNV LVVLSVFTYK PLRIVQNFFI VSLAVADLTV AVLVMPFNVA YSLIQRWVFG
     IVVCKMWLTC DVLCCTASIL NLCAIALDRY WAITDPINYA QKRTLRRVLA MIAGVWLLSG
     VISSPPLIGW NDWPMEFNDT TPCQLTEEQG YVIYSSLGSF FIPLFIMTIV YVEIFIATKR
     RLRERAKASK LNSAMKQQMA AQAVPSSVPS HDQESVSSET NHNELPPPPA PPSKEKRRKT
     KKKSKKKEQA AEEGRFLAPA MVAEDSVTDN SVSVGPVARN HLAEDGYTCT TTTTTTTTTT
     AVTDSPRSRT ASQKGSTAPP TPVQPKSIPV YQFIEEKQRI SLSKERRAAR TLGIIMGVFV
     VCWLPFFLMY VIVPFCNPSC KPSPKLVNFI TWLGYINSAL NPIIYTIFNL DFRRAFKKLL
     HFKT