ID   OAR1_LYMST              Reviewed;         638 AA.
AC   O77408;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Octopamine receptor 1;
DE            Short=OA1;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   TISSUE=CNS;
RX   PubMed=9203635; DOI=10.1124/mol.51.2.293;
RA   Gerhardt C.C., Bakker R.A., Piek G.J., Planta R.J., Vreugdenhil E.,
RA   Leysen J.E., van Heerikhuizen H.;
RT   "Molecular cloning and pharmacological characterization of a molluscan
RT   octopamine receptor.";
RL   Mol. Pharmacol. 51:293-300(1997).
CC   -!- FUNCTION: G-protein coupled receptor for octopamine (OA), which is a
CC       neurotransmitter, neurohormone, and neuromodulator in invertebrates.
CC       Activation of this receptor by octopamine induces an increase in both
CC       inositol phosphates and cyclic AMP. The coupling to adenylyl cyclase
CC       seems to be less efficient than the coupling to phospholipase C. The
CC       rank order of potency for agonists is p-synephrine >= clonidine > p-
CC       octopamine = xylometazoline = phenylephrine = oxymetazoline > B-HT920 >
CC       serotonin = p-tyramine > epinephrine > norepinephrine > methoxamine =
CC       dopamine = histamine. For antagonists, the rank order is yohimbine >
CC       chlopromazine / spiperone > phentolamine > mianserine > rauwolscine >
CC       prazosin > alprenolol / propanolol > pindolol.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the central nervous system.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U62771; AAC61296.1; -; mRNA.
DR   AlphaFoldDB; O77408; -.
DR   SMR; O77408; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000995; Musac_Ach_rcpt.
DR   Pfam; PF00001; 7tm_1; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00243; MUSCARINICR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..638
FT                   /note="Octopamine receptor 1"
FT                   /id="PRO_0000069956"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..167
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..239
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..259
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..520
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        521..545
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        546..551
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..575
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        576..638
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          618..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        215
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..230
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   638 AA;  70001 MW;  65FA928B5C01D34F CRC64;
     MSRDIFMKRL RLHLLFDEVA MVTHIVGDVL SSVLLCAVVL LVLVGNTLVV AAVATSRKLR
     TVTNVFIVNL ACADLLLGVL VLPFSAVNEI KDVWIFGHVW CQVWLAVDVW LCTASILNLC
     CISLDRYLAI TRPIRYPGLM SAKRAKTLVA GVWLFSFVIC CPPLIGWNDG GDGIMDYNGT
     TATPIPVTTT QTPVTGRDDV LCDNGFNYST NSNMNTTCTY SGDSSLSTTC ELTNSRGYRI
     YAALGSFFIP MLVMVFFYLQ IYRAAVKTIS AYAKGELKTK YSVRENGSKT NSVTLRIHRG
     GRGPSTGSSV YRHGSTYGGS AAGAATREGC GDKDAAGGRR FGRQEMDSHL PVRKCRSSDA
     SLVTLTGLKC EIIDNGNAKH GPISELIKGR GKSFFWRKEK KRSVGGERES FENSTRNGRS
     TRAKLCGGRC LAIETDICSS GECSPRTKRI KEHARATQHN SLPVTPSLSS QNEETDAVFV
     RGTSNSEYKP RRSRLSAHKP GHAMRLHMQK FNREKKAAKT LAIIVGAFIM CWMPFFTIYL
     VGAFCENCIS PIVFSVAFWL GYCNSAMNPC VYALFSRDFR FAFRKLLTCS CKAWSKNRSF
     RPQTSDVPAI QLHCATQDDA KSSSDIGPTA SGGNGGYT