ID   OAR2_LOCMI              Reviewed;         484 AA.
AC   Q25322;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative tyramine receptor 2;
DE   AltName: Full=Tyr-Loc2;
GN   Name=GCR2;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuron;
RA   Vanden Broeck J.J.M.;
RL   Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: G-protein coupled receptor for tyramine, a known
CC       neurotransmitter and neuromodulator and direct precursor of octopamine.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X69521; CAA49269.1; -; mRNA.
DR   AlphaFoldDB; Q25322; -.
DR   SMR; Q25322; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004989; F:octopamine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002002; Octopmn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00664; OCTOPAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..484
FT                   /note="Putative tyramine receptor 2"
FT                   /id="PRO_0000069955"
FT   TOPO_DOM        1..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..109
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..126
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..411
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..433
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        434..448
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..470
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        471..484
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          253..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        13
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   484 AA;  53489 MW;  15C10608471D77CD CRC64;
     MVRVELQAAS LMNGSSAAEE PQDALVGGDA CGGRRPPSVL GVRLAVPEWE VAVTAVSLSL
     IILITIVGNV LVVLSVFTYK PLRIVQNFFI VSLAVADLTV AVLVMPFNVA YSLIQRWVFG
     IVVCKMWLTC DVLCCTASIL NLCAIALDRY WAITDPINYA QKRTLRRVLA MIAGVWLLSG
     VISSPPLIGW NDWPMEFNDT TPCQLTEEQG YVIYSSLGSF FIPLFIMTIV YVEIFIATKR
     RLRERAKASK LNSAMKQQMA AQAVPSSVPS HDQESVSSET NHNELPPPPA PPSKEKRRKT
     KKKSKKKDQA AEEGRFLAPA MVAEDSVTDN SVSVGPVAKN HLAEDGYTCT TTTTTTTTTT
     AVTDSPRSRT ASQKGSTAPP TPVQPKSIPV YQFIEEKQRI SLSKERRAAR TLGIIMGVFV
     VCWLPFFLMY VIVPFCNPSC KPSPKLVNFI TWLGYINSAL NPIIYTIFNL DFRRAFKKLL
     HFKT