ARRC_ICTTR
ID ARRC_ICTTR Reviewed; 393 AA.
AC Q5DRQ4;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Arrestin-C;
DE AltName: Full=Cone arrestin;
DE Short=cArr;
DE AltName: Full=Retinal cone arrestin-3;
GN Name=ARR3;
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yan W., Wang C., Zack D.;
RT "Molecular cloning and characterization of retinal-enriched genes in the
RT 13-lined ground squirrel, a cone dominant mammalian animal model.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in an as yet undefined retina-specific signal
CC transduction. Could bind to photoactivated-phosphorylated red/green
CC opsins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked in response to retinal
CC illumination (By similarity). Interacts with CXCR4; the interaction is
CC dependent on the C-terminal phosphorylation of CXCR4 and modulates the
CC calcium ion mobilization activity of CXCR4 (By similarity).
CC {ECO:0000250|UniProtKB:P36575, ECO:0000250|UniProtKB:Q9N0H5}.
CC -!- SUBCELLULAR LOCATION: Photoreceptor inner segment
CC {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor
CC outer segment {ECO:0000250|UniProtKB:Q9EQP6}.
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; AY517478; AAS89816.1; -; mRNA.
DR RefSeq; NP_001269195.1; NM_001282266.1.
DR AlphaFoldDB; Q5DRQ4; -.
DR SMR; Q5DRQ4; -.
DR STRING; 43179.ENSSTOP00000010290; -.
DR GeneID; 101966281; -.
DR CTD; 407; -.
DR eggNOG; KOG3865; Eukaryota.
DR InParanoid; Q5DRQ4; -.
DR OrthoDB; 783081at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.640; -; 1.
DR Gene3D; 2.60.40.840; -; 1.
DR InterPro; IPR033042; ARR3.
DR InterPro; IPR000698; Arrestin.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR017864; Arrestin_CS.
DR InterPro; IPR014753; Arrestin_N.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11792; PTHR11792; 1.
DR PANTHER; PTHR11792:SF19; PTHR11792:SF19; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR PRINTS; PR00309; ARRESTIN.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; SSF81296; 2.
DR PROSITE; PS00295; ARRESTINS; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Disulfide bond; Reference proteome; Sensory transduction;
KW Vision.
FT CHAIN 1..393
FT /note="Arrestin-C"
FT /id="PRO_0000250488"
FT REGION 371..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43416 MW; 218D70F9CEEB03FC CRC64;
MASSSKVFKK TSSNGKLSIY LGKRDFMDHV DTVEPIDGVV LVDPEYLKGR KMFVILTCAF
RYGRDDLDVI GLTFRKDLYV LTQQVVPAES NSPQGPLTVL QERLLHKLGE NAYPFTLQMV
ANLPCSVTLQ PGPEDSGKAC GVDFEVKSFC AENLEEKVSK RDSVRLVVRK VQFAPMEPGP
GPWAQTIRRF LLSVQPLQLQ AWMDKEVHYH GEPISVNVSI NNSTSKVIKK IKISVDQITD
VVLYSLDKYT KTVFIQEFTE TIAANSSFTQ SFSVTPLLSA NCRRQGLALD GKLKHEDTNL
ASSTIVRPGM NKELLGILVS YKVRVNLMVS CGGILGDLTA SDVGVELPLT LIHPKPSQET
TSSEDIVIEE FARQEDGGEE KQKALAEEGD EGS