位置:首页 > 蛋白库 > ARRC_ICTTR
ARRC_ICTTR
ID   ARRC_ICTTR              Reviewed;         393 AA.
AC   Q5DRQ4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Arrestin-C;
DE   AltName: Full=Cone arrestin;
DE            Short=cArr;
DE   AltName: Full=Retinal cone arrestin-3;
GN   Name=ARR3;
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yan W., Wang C., Zack D.;
RT   "Molecular cloning and characterization of retinal-enriched genes in the
RT   13-lined ground squirrel, a cone dominant mammalian animal model.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in an as yet undefined retina-specific signal
CC       transduction. Could bind to photoactivated-phosphorylated red/green
CC       opsins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked in response to retinal
CC       illumination (By similarity). Interacts with CXCR4; the interaction is
CC       dependent on the C-terminal phosphorylation of CXCR4 and modulates the
CC       calcium ion mobilization activity of CXCR4 (By similarity).
CC       {ECO:0000250|UniProtKB:P36575, ECO:0000250|UniProtKB:Q9N0H5}.
CC   -!- SUBCELLULAR LOCATION: Photoreceptor inner segment
CC       {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor
CC       outer segment {ECO:0000250|UniProtKB:Q9EQP6}.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY517478; AAS89816.1; -; mRNA.
DR   RefSeq; NP_001269195.1; NM_001282266.1.
DR   AlphaFoldDB; Q5DRQ4; -.
DR   SMR; Q5DRQ4; -.
DR   STRING; 43179.ENSSTOP00000010290; -.
DR   GeneID; 101966281; -.
DR   CTD; 407; -.
DR   eggNOG; KOG3865; Eukaryota.
DR   InParanoid; Q5DRQ4; -.
DR   OrthoDB; 783081at2759; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.640; -; 1.
DR   Gene3D; 2.60.40.840; -; 1.
DR   InterPro; IPR033042; ARR3.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR017864; Arrestin_CS.
DR   InterPro; IPR014753; Arrestin_N.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11792; PTHR11792; 1.
DR   PANTHER; PTHR11792:SF19; PTHR11792:SF19; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Disulfide bond; Reference proteome; Sensory transduction;
KW   Vision.
FT   CHAIN           1..393
FT                   /note="Arrestin-C"
FT                   /id="PRO_0000250488"
FT   REGION          371..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  43416 MW;  218D70F9CEEB03FC CRC64;
     MASSSKVFKK TSSNGKLSIY LGKRDFMDHV DTVEPIDGVV LVDPEYLKGR KMFVILTCAF
     RYGRDDLDVI GLTFRKDLYV LTQQVVPAES NSPQGPLTVL QERLLHKLGE NAYPFTLQMV
     ANLPCSVTLQ PGPEDSGKAC GVDFEVKSFC AENLEEKVSK RDSVRLVVRK VQFAPMEPGP
     GPWAQTIRRF LLSVQPLQLQ AWMDKEVHYH GEPISVNVSI NNSTSKVIKK IKISVDQITD
     VVLYSLDKYT KTVFIQEFTE TIAANSSFTQ SFSVTPLLSA NCRRQGLALD GKLKHEDTNL
     ASSTIVRPGM NKELLGILVS YKVRVNLMVS CGGILGDLTA SDVGVELPLT LIHPKPSQET
     TSSEDIVIEE FARQEDGGEE KQKALAEEGD EGS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024