ID   OAR_BOMMO               Reviewed;         479 AA.
AC   Q17232;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Octopamine receptor;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Antenna;
RX   PubMed=9014328; DOI=10.1016/s0965-1748(96)00031-8;
RA   von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J.,
RA   Strotmann J., Breer H.;
RT   "Cloning of biogenic amine receptors from moths (Bombyx mori and Heliothis
RT   virescens).";
RL   Insect Biochem. Mol. Biol. 26:817-827(1996).
CC   -!- FUNCTION: Receptor for octopamine. Octopamine (OA) is a
CC       neurotransmitter, neurohormone, and neuromodulator in invertebrates.
CC       The activity of this receptor is mediated by G proteins which activate
CC       adenylyl cyclase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X95607; CAA64865.1; -; mRNA.
DR   RefSeq; NP_001037504.1; NM_001044039.1.
DR   AlphaFoldDB; Q17232; -.
DR   SMR; Q17232; -.
DR   STRING; 7091.BGIBMGA011067-TA; -.
DR   GeneID; 693055; -.
DR   KEGG; bmor:693055; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_11_1_1; -.
DR   OrthoDB; 737211at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004989; F:octopamine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002002; Octopmn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00664; OCTOPAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..479
FT                   /note="Octopamine receptor"
FT                   /id="PRO_0000069952"
FT   TOPO_DOM        1..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..80
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..90
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..112
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..129
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..193
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..240
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..407
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..429
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        430..441
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        463..479
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          260..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..316
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   479 AA;  54518 MW;  CADA024567EC3620 CRC64;
     MGQAATHDAN NYTSINYTEI YDVIEDEKDV CAVADEPNIP CSFGISLAVP EWEAICTAII
     LTMIIISTVV GNILVILSVF TYKPLRIVQN FFIVSLAVAD LTVAILVLPL NVAYSILGQW
     VFGIYVCKMW LTCDIMCCTS SILNLCAIAL DRYWAITDPI NYAQKRTLER VLFMIGIVWI
     LSLVISSPPL LGWNDWPEVF EPDTPCRLTS QPGFVIFSSS GSFYIPLVIM TVVYFEIYLA
     TKKRLRDRAK ATKISTISSG RNKYETKESD PNDQDSVSSD ANPNEHQGGT RLVAENEKKH
     RTRKLTPKKK PKRRYWSKDD KSHNKLIIPI LSNENSVTDI GENLENRNTS SESNSKETHE
     DNMIEITEAA PVKIQKRPKQ NQTNAVYQFI EEKQRISLTR ERRAARTLGI IMGVFVVCWL
     PFFVIYLVIP FCVSCCLSNK FINFITWLGY VNSALNPLIY TIFNMDFRRA FKKLLFIKC