ID   OAR_HELVI               Reviewed;         477 AA.
AC   Q25188;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Octopamine receptor;
OS   Heliothis virescens (Tobacco budworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Heliothis.
OX   NCBI_TaxID=7102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Antenna;
RX   PubMed=9014328; DOI=10.1016/s0965-1748(96)00031-8;
RA   von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J.,
RA   Strotmann J., Breer H.;
RT   "Cloning of biogenic amine receptors from moths (Bombyx mori and Heliothis
RT   virescens).";
RL   Insect Biochem. Mol. Biol. 26:817-827(1996).
CC   -!- FUNCTION: Receptor for octopamine. Octopamine (OA) is a
CC       neurotransmitter, neurohormone, and neuromodulator in invertebrates.
CC       The activity of this receptor is mediated by G proteins which activate
CC       adenylyl cyclase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X95606; CAA64864.1; -; mRNA.
DR   AlphaFoldDB; Q25188; -.
DR   SMR; Q25188; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004989; F:octopamine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002002; Octopmn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00664; OCTOPAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..477
FT                   /note="Octopamine receptor"
FT                   /id="PRO_0000069953"
FT   TOPO_DOM        1..55
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..78
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..110
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..127
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..191
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..216
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..238
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..405
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..427
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        428..439
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        461..477
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          256..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..277
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   477 AA;  54282 MW;  714CF0322AF7CA99 CRC64;
     MGQAATHVDA NYTLINYTEE VIEDDRDACA VADDPKYPSS FGITLAVPEW EAICTAIVLT
     LIIISTIVGN ILVILSVFTY KPLRIVQNFF IVSLAVADLT VAILVLPLNV AYSILGQWVF
     GIYVCKMWLT CDIMCCTSSI LNLCAIALDR YWAITDPINY AQKRTLERVL LMIGVVWVLS
     LIISSPPLLG WNDWPDVFEP DTPCRLTSQP GFVIFSSSGS FYIPLVIMTV VYFEIYLATK
     KRLRDRAKAT KISTISSGQN KYNNKDDHHD QDSVSSEANH NEHQGVTRLV SDNEKKKRTR
     KLTPKKKPKR KYWSKDDKSQ NKLIIPILSN ENSVTDMGEN LENRNTSSES NSKETHEDDL
     IEVNETVPVK THHKKPKPNQ QSAVYQFIEE KQRISLTRER RAARTLGIIM GVFVVCWLPF
     FVIYLVIPFC ASCCLSNKFI NFITWLGYCN SALNPLIYTI FNMDFRRAFK KLLCMKP