OAS1B_RAT
ID OAS1B_RAT Reviewed; 379 AA.
AC Q5BKD0; O70522;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Inactive 2'-5'-oligoadenylate synthase 1B;
DE Short=(2-5')oligo(A) synthase 1B;
DE Short=2-5A synthase 1B;
GN Name=Oas1b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12650929; DOI=10.1016/s0014-5793(03)00200-x;
RA Shimizu T., Kawakita S., Li Q.-H., Fukuhara S., Fujisawa J.;
RT "Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-
RT responsive enhancer element via NF-kappaB activity.";
RL FEBS Lett. 539:73-77(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP REVIEW.
RX PubMed=17024523; DOI=10.1007/s00239-006-0073-3;
RA Perelygin A.A., Zharkikh A.A., Scherbik S.V., Brinton M.A.;
RT "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for
RT concerted evolution of paralogous Oas1 genes in Rodentia and
RT Artiodactyla.";
RL J. Mol. Evol. 63:562-576(2006).
CC -!- FUNCTION: Does not have 2'-5'-OAS activity, but can bind double-
CC stranded RNA. Displays antiviral activity against viruses via an
CC alternative antiviral pathway independent of RNase L (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with OSBPL1A and ABCF3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type IV membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the brain, liver, spleen and
CC heart. {ECO:0000269|PubMed:12650929}.
CC -!- SIMILARITY: Belongs to the 2-5A synthase family. {ECO:0000305}.
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DR EMBL; AF068268; AAC19135.1; -; mRNA.
DR EMBL; CH473973; EDM13762.1; -; Genomic_DNA.
DR EMBL; BC091121; AAH91121.1; -; mRNA.
DR RefSeq; NP_653353.2; NM_144752.2.
DR AlphaFoldDB; Q5BKD0; -.
DR SMR; Q5BKD0; -.
DR STRING; 10116.ENSRNOP00000001853; -.
DR PaxDb; Q5BKD0; -.
DR Ensembl; ENSRNOT00000048782; ENSRNOP00000042591; ENSRNOG00000033220.
DR GeneID; 246268; -.
DR KEGG; rno:246268; -.
DR UCSC; RGD:708393; rat.
DR CTD; 23961; -.
DR RGD; 708393; Oas1b.
DR eggNOG; KOG0001; Eukaryota.
DR GeneTree; ENSGT00510000046406; -.
DR InParanoid; Q5BKD0; -.
DR OrthoDB; 611234at2759; -.
DR PhylomeDB; Q5BKD0; -.
DR TreeFam; TF329749; -.
DR PRO; PR:Q5BKD0; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Proteomes; UP000234681; Chromosome 12.
DR Bgee; ENSRNOG00000033220; Expressed in lung and 19 other tissues.
DR ExpressionAtlas; Q5BKD0; baseline and differential.
DR Genevisible; Q5BKD0; RN.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001730; F:2'-5'-oligoadenylate synthetase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
DR GO; GO:0060700; P:regulation of ribonuclease activity; IBA:GO_Central.
DR GO; GO:0009615; P:response to virus; ISS:UniProtKB.
DR CDD; cd05400; NT_2-5OAS_ClassI-CCAase; 1.
DR Gene3D; 3.30.460.10; -; 1.
DR InterPro; IPR018952; 2-5-oligoAdlate_synth_1_dom2/C.
DR InterPro; IPR026774; 2-5A_synthase.
DR InterPro; IPR006116; NT_2-5OAS_ClassI-CCAase.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR PANTHER; PTHR11258; PTHR11258; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF10421; OAS1_C; 1.
DR SUPFAM; SSF81301; SSF81301; 1.
DR PROSITE; PS50152; 25A_SYNTH_3; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Endoplasmic reticulum; Immunity; Innate immunity;
KW Membrane; Reference proteome; RNA-binding; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..379
FT /note="Inactive 2'-5'-oligoadenylate synthase 1B"
FT /id="PRO_0000418626"
FT TOPO_DOM 1..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..374
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CONFLICT 117
FT /note="V -> M (in Ref. 1; AAC19135)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="Q -> H (in Ref. 1; AAC19135)"
FT /evidence="ECO:0000305"
FT CONFLICT 172..173
FT /note="NL -> IF (in Ref. 1; AAC19135)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="T -> N (in Ref. 1; AAC19135)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 44122 MW; FDD7CD575D87B4BD CRC64;
MEQELRSIPA SKLDQFIEVH LPDISFRDEL REVIDVLCIL LKNRCCRESS HPVRTSKVGK
GGSSRKGTTL KGWSDADLVV FLDSFTCFGD QLNRRGEFTK EIKKLLFEVQ RDRHIGVKIE
VHSSWSPNHR ALSFKLSAPD QQKEVKFDVL PAYDLLGHVC IPRKPNPQFY ANLISERTSL
GKEDEFSTCF TELQLYFLNW RPTKLKSLIR LVKHWYQLCK EKLGDPLPPQ YALELLTIYA
WERGGRLTKF NTAQGFRTVL ELITKYKQLL IYWTVCYDFQ HPEVSKYLRR QLKKPRPVIL
DPANPTGNIA GSNPKGWRRL AGEAAAWLRY PCFKYKDGFP VCPWDVPTEV DIPSQNYFFH
IICLIFWLLL RLIFGKHSV
