ID   A27_VACCC               Reviewed;         110 AA.
AC   P20535;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 73.
DE   RecName: Full=14 kDa fusion protein;
GN   ORFNames=A27L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Structural protein involved in the envelopment of mature
CC       virion (MV) to form the wrapped virion (WV). The wrapping consists of
CC       the addition of Golgi membranes to the mature virion. Participates in
CC       mature virion (MV) movement within the infected cell. May play an
CC       indirect role in MV-cell fusion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamers, covalently linked. Interacts with A17 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Located to the mature virion
CC       membrane via interaction with protein A17. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A27 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48152.1; -; Genomic_DNA.
DR   PIR; B42520; WMVZ2U.
DR   BMRB; P20535; -.
DR   SMR; P20535; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR   InterPro; IPR003436; Chordopox_Fusion/A27.
DR   Pfam; PF02346; Vac_Fusion; 1.
DR   PRINTS; PR01847; VIRALFUSION.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Virion.
FT   CHAIN           1..110
FT                   /note="14 kDa fusion protein"
FT                   /id="PRO_0000099211"
SQ   SEQUENCE   110 AA;  12616 MW;  4AF71F2C740A453E CRC64;
     MDGTLFPGDD DLAIPATEFF STKADKKPEA KREAIVKADE DDNEETLKQR LTNLEKKITN
     VTTKFEQIEK CCKRNDEVLF RLENHAETLR AAMISLAKKI DVQTGRRPYE