OAT_BACCQ
ID OAT_BACCQ Reviewed; 396 AA.
AC B9ITF9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Ornithine aminotransferase {ECO:0000255|HAMAP-Rule:MF_01689};
DE Short=OAT {ECO:0000255|HAMAP-Rule:MF_01689};
DE EC=2.6.1.13 {ECO:0000255|HAMAP-Rule:MF_01689};
DE AltName: Full=Ornithine--oxo-acid aminotransferase {ECO:0000255|HAMAP-Rule:MF_01689};
GN Name=rocD {ECO:0000255|HAMAP-Rule:MF_01689}; OrderedLocusNames=BCQ_1211;
OS Bacillus cereus (strain Q1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=361100;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Q1;
RX PubMed=19060151; DOI=10.1128/jb.01629-08;
RA Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X.,
RA Xue Y., Zhu Y., Jin Q.;
RT "Complete genome sequence of the extremophilic Bacillus cereus strain Q1
RT with industrial applications.";
RL J. Bacteriol. 191:1120-1121(2009).
CC -!- FUNCTION: Catalyzes the interconversion of ornithine to glutamate
CC semialdehyde. {ECO:0000255|HAMAP-Rule:MF_01689}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-
CC glutamate 5-semialdehyde; Xref=Rhea:RHEA:13877, ChEBI:CHEBI:35179,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:58066, ChEBI:CHEBI:59869; EC=2.6.1.13;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01689};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01689};
CC -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate
CC 5-semialdehyde from L-ornithine: step 1/1. {ECO:0000255|HAMAP-
CC Rule:MF_01689}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01689}.
CC -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC aminotransferase family. OAT subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_01689}.
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DR EMBL; CP000227; ACM11641.1; -; Genomic_DNA.
DR RefSeq; WP_000616655.1; NC_011969.1.
DR AlphaFoldDB; B9ITF9; -.
DR SMR; B9ITF9; -.
DR EnsemblBacteria; ACM11641; ACM11641; BCQ_1211.
DR GeneID; 59159565; -.
DR GeneID; 64200161; -.
DR KEGG; bcq:BCQ_1211; -.
DR HOGENOM; CLU_016922_10_3_9; -.
DR OMA; DVFPRFA; -.
DR UniPathway; UPA00098; UER00358.
DR Proteomes; UP000000441; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0050155; F:ornithine(lysine) transaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004587; F:ornithine-oxo-acid transaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_01689; Ornith_aminotrans_3; 1.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR010164; Orn_aminotrans.
DR InterPro; IPR034757; Ornith_aminotrans_bact.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11986:SF18; PTHR11986:SF18; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR TIGRFAMs; TIGR01885; Orn_aminotrans; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aminotransferase; Cytoplasm; Proline biosynthesis;
KW Pyridoxal phosphate; Transferase.
FT CHAIN 1..396
FT /note="Ornithine aminotransferase"
FT /id="PRO_1000187438"
FT MOD_RES 255
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01689"
SQ SEQUENCE 396 AA; 43229 MW; 68EFFB9B3237DB08 CRC64;
MIQTKDIIEL TDTYGANNYH PLPIVISKAE GVWVEDPEGN RYMDLLSAYS AVNQGHRHPK
IINALIDQAN RVTLTSRAFH SDQLGPWYEK VAKLTNKEMV LPMNTGAEAV ETAIKTARRW
AYDVKKVEAN RAEIIVCEDN FHGRTMGAVS MSSNEEYKRG FGPMLPGIVV IPYGDLEALK
AAITPNTAAF ILEPIQGEAG INIPPAGFLK EALEVCKKEN VLFVADEIQT GLGRTGKVFA
CDWDGVTPDM YILGKALGGG VFPISCVAAN RDILGVFEPG SHGSTFGGNP LACAVSIAAL
EVLEEEKLTE RSLQLGEKLV GQLKEIDNPM ITEVRGKGLF IGIELNEPAR PYCEQLKAAG
LLCKETHENV IRIAPPLVIS EEDLEWAFQK IKAVLS