OAZ1_CHICK
ID OAZ1_CHICK Reviewed; 216 AA.
AC O42148;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Ornithine decarboxylase antizyme 1;
DE Short=ODC-Az;
GN Name=OAZ;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9524208; DOI=10.1016/s0167-4781(97)00162-0;
RA Drozdowski B.J., Gong T.-W.L., Lomax M.I.;
RT "The chicken cDNA for ornithine decarboxylase antizyme.";
RL Biochim. Biophys. Acta 1396:21-26(1998).
CC -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC negatively regulates ODC activity and intracellular polyamine
CC biosynthesis and uptake in response to increased intracellular
CC polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC functional ODC homodimer, and targets the monomers for ubiquitin-
CC independent proteolytic destruction by the 26S proteasome.
CC {ECO:0000250|UniProtKB:P54368}.
CC -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Ribosomal frameshifting; Named isoforms=1;
CC Comment=A ribosomal frameshift occurs between the codons for Ser-58
CC and Asp-59. An autoregulatory mechanism enables modulation of
CC frameshifting according to the cellular concentration of polyamines.;
CC Name=1;
CC IsoId=O42148-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR EMBL; AF007806; AAC97533.1; -; mRNA.
DR RefSeq; NP_990247.1; NM_204916.1. [O42148-1]
DR AlphaFoldDB; O42148; -.
DR SMR; O42148; -.
DR STRING; 9031.ENSGALP00000040427; -.
DR PaxDb; O42148; -.
DR Ensembl; ENSGALT00000082265; ENSGALP00000055863; ENSGALG00000000812. [O42148-1]
DR GeneID; 395746; -.
DR KEGG; gga:395746; -.
DR CTD; 4946; -.
DR VEuPathDB; HostDB:geneid_395746; -.
DR eggNOG; KOG4387; Eukaryota.
DR GeneTree; ENSGT00940000159808; -.
DR HOGENOM; CLU_085486_2_0_1; -.
DR InParanoid; O42148; -.
DR OMA; TRIFNVQ; -.
DR OrthoDB; 1403675at2759; -.
DR PhylomeDB; O42148; -.
DR PRO; PR:O42148; -.
DR Proteomes; UP000000539; Chromosome 28.
DR Bgee; ENSGALG00000000812; Expressed in spermatid and 14 other tissues.
DR ExpressionAtlas; O42148; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006595; P:polyamine metabolic process; IEA:InterPro.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.40.630.60; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR029914; ODC-AZ_1.
DR InterPro; IPR002993; ODC_AZ.
DR InterPro; IPR038581; ODC_AZ_sf.
DR PANTHER; PTHR10279; PTHR10279; 1.
DR PANTHER; PTHR10279:SF8; PTHR10279:SF8; 1.
DR Pfam; PF02100; ODC_AZ; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS01337; ODC_AZ; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ribosomal frameshifting.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..216
FT /note="Ornithine decarboxylase antizyme 1"
FT /id="PRO_0000220853"
SQ SEQUENCE 216 AA; 24315 MW; D1A708113DA091A8 CRC64;
MVKSSLQRIL NSHCFAREKE GNKSTIMPAV LSLSTGQSSS RVPFNCCSNL GPGPRWCSDV
PHPPLKIPGG RGNSQRDHNL SANLFYSDNR LNVTEELTSN NRTRILNVQS RLTDAKHISW
RAVLNNNNLY IEIPSGALPE GSKDSFAVLL EFAEEQLQVD HVFICFHKNR DDRAALLRTF
SFLGFEIVRP GHPLVPKRPD ACFMAYTFER DSSEEE
