ID   OAZ1_DANRE              Reviewed;         214 AA.
AC   Q9YI98;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Ornithine decarboxylase antizyme 1;
DE   AltName: Full=ODC antizyme, short form;
DE            Short=ODC-Az-S;
GN   Name=oaz1a; Synonyms=oaz1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10600644; DOI=10.1042/bj3450099;
RA   Saito T., Hascilowicz T., Ohkido I., Kikuchi Y., Okamoto H., Hayashi S.,
RA   Murakami Y., Matsufuji S.;
RT   "Two zebrafish (Danio rerio) antizymes with different expression and
RT   activities.";
RL   Biochem. J. 345:99-106(2000).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-55
CC         and Asp-56. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q9YI98-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AB017117; BAA74769.1; -; mRNA.
DR   RefSeq; NP_919240.2; NM_194264.2. [Q9YI98-1]
DR   AlphaFoldDB; Q9YI98; -.
DR   SMR; Q9YI98; -.
DR   STRING; 7955.ENSDARP00000096305; -.
DR   PaxDb; Q9YI98; -.
DR   Ensembl; ENSDART00000105532; ENSDARP00000096305; ENSDARG00000071403. [Q9YI98-1]
DR   GeneID; 259192; -.
DR   KEGG; dre:259192; -.
DR   CTD; 259192; -.
DR   ZFIN; ZDB-GENE-020731-4; oaz1a.
DR   eggNOG; KOG4387; Eukaryota.
DR   GeneTree; ENSGT00940000159808; -.
DR   HOGENOM; CLU_085486_2_1_1; -.
DR   InParanoid; Q9YI98; -.
DR   OMA; CAEEKLQ; -.
DR   OrthoDB; 1403675at2759; -.
DR   PhylomeDB; Q9YI98; -.
DR   Reactome; R-DRE-350562; Regulation of ornithine decarboxylase (ODC).
DR   PRO; PR:Q9YI98; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000071403; Expressed in brain and 28 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; ISS:UniProtKB.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR029914; ODC-AZ_1.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   PANTHER; PTHR10279:SF8; PTHR10279:SF8; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   2: Evidence at transcript level;
KW   Polyamine biosynthesis; Reference proteome; Ribosomal frameshifting.
FT   CHAIN           1..214
FT                   /note="Ornithine decarboxylase antizyme 1"
FT                   /id="PRO_0000220854"
SQ   SEQUENCE   214 AA;  24355 MW;  75A842FAE430B5F9 CRC64;
     MVKSNLQTIL NSHCFVREKE SNIPKMPVIE LTRNKPESES SHRCSNPCPG PLWCSDVPLP
     PLKIPGGRGN DQRDHSLSAK LFYSDAQLLV LEEAPQSNSR VRFLLFERRC SVSKHLVWRG
     ALKGTNLYIE IPTGVLPEGS KDSFSLLLEF AEEKLQVDHV FICFHKSRDD RASLLRTFSF
     MGFEIVRPGH PLVPTRPDAF FMAYRIERDS DGDE