ID   OAZ1_MESAU              Reviewed;         222 AA.
AC   P70112;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Ornithine decarboxylase antizyme 1;
DE            Short=ODC-Az;
GN   Name=OAZ1; Synonyms=OAZ;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9692545; DOI=10.1038/sj.onc.1201887;
RA   Tsuji T., Todd R., Meyer C., McBride J., Liao P.H., Huang M.F., Chou M.Y.,
RA   Donoff R.B., Wong D.T.;
RT   "Reduction of ornithine decarboxylase antizyme (ODC-Az) level in the 7,12-
RT   dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis
RT   model.";
RL   Oncogene 16:3379-3385(1998).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome. Triggers ODC
CC       degradation by inducing the exposure of a cryptic proteasome-
CC       interacting surface of ODC. Stabilizes AZIN2 by interfering with its
CC       ubiquitination. Also inhibits cellular uptake of polyamines by
CC       inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex
CC       mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved
CC       in the translocation of AZIN2 from ER-Golgi intermediate compartment
CC       (ERGIC) to the cytosol. {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. Forms a ternary complex with PSMB4 and OAZ1 before
CC       PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2;
CC       this interaction disrupts the interaction between the antizyme and
CC       ODC1. Interacts with FAM171A1 (By similarity).
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-68
CC         and Tyr-69. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=P70112-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; U58672; AAB07365.1; -; mRNA.
DR   RefSeq; NP_001268250.2; NM_001281321.2.
DR   AlphaFoldDB; P70112; -.
DR   SMR; P70112; -.
DR   STRING; 10036.XP_005083341.1; -.
DR   GeneID; 101826304; -.
DR   CTD; 4946; -.
DR   eggNOG; KOG4387; Eukaryota.
DR   OrthoDB; 1403675at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; ISS:UniProtKB.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR029914; ODC-AZ_1.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   PANTHER; PTHR10279:SF8; PTHR10279:SF8; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   2: Evidence at transcript level;
KW   Polyamine biosynthesis; Reference proteome; Ribosomal frameshifting;
KW   Transport.
FT   CHAIN           1..222
FT                   /note="Ornithine decarboxylase antizyme 1"
FT                   /id="PRO_0000220850"
SQ   SEQUENCE   222 AA;  24675 MW;  C0C97B0FED8B9B13 CRC64;
     MVKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS RAALHCCSNL
     GPGPRWCSYV PHPPLKIPGG RGNSQRDHSL SASVLYSDER LNVTEEPTAN DKTRVLSIQS
     RLTEAKQVTW RAVWNGGGLY IELPAGPSPE GSKDSFAALL EFAEEQLQAD HVFICFPKNR
     EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMVYTLER ED