ID   OAZ1_XENLA              Reviewed;         216 AA.
AC   P55814;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Ornithine decarboxylase antizyme 1;
DE            Short=ODC-Az;
GN   Name=oaz1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7772605; DOI=10.1016/0167-4781(95)00062-l;
RA   Ichiba T., Matsufuji S., Miyazaki Y., Hayashi S.;
RT   "Nucleotide sequence of ornithine decarboxylase antizyme cDNA from Xenopus
RT   laevis.";
RL   Biochim. Biophys. Acta 1262:83-86(1995).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-58
CC         and Asp-59. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=P55814-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; D32141; BAA06867.1; -; mRNA.
DR   PIR; S55682; S55682.
DR   AlphaFoldDB; P55814; -.
DR   SMR; P55814; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; ISS:UniProtKB.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR029914; ODC-AZ_1.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   PANTHER; PTHR10279:SF8; PTHR10279:SF8; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   2: Evidence at transcript level;
KW   Polyamine biosynthesis; Reference proteome; Ribosomal frameshifting.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..216
FT                   /note="Ornithine decarboxylase antizyme 1"
FT                   /id="PRO_0000220856"
SQ   SEQUENCE   216 AA;  24414 MW;  47448349E9AE0DC5 CRC64;
     MVKSSLQRIL NSHCFAREKE GNKRNDAMPL LSIPSSSESS RASFNCCSNL GPGPRWCSDV
     PHPPLKIPGG RGNSQRDHNL SANLFYSDNR LNITEELTSN NRTRILNVQS SLTDGKQVSW
     RAVLNNNNLY IEIPSGTLPD GSKDSFAILL EYAEEQLQVD HVFICFHKNR DDRAMLLRTF
     RFLGFEIVIP GHPLVPKRPD ACFMAYTFER DSSDED