ARRD2_HUMAN
ID ARRD2_HUMAN Reviewed; 407 AA.
AC Q8TBH0; B2RBG9; O95895; Q6ZRV9; Q8WYG6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Arrestin domain-containing protein 2;
GN Name=ARRDC2; ORFNames=PP2703;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Synovial cell, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS HIS-181;
RP HIS-192 AND PRO-396.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-407.
RC TISSUE=Brain;
RA Mei G., Yu W., Gibbs R.A.;
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH WWP1.
RX PubMed=21191027; DOI=10.1128/jvi.02045-10;
RA Rauch S., Martin-Serrano J.;
RT "Multiple interactions between the ESCRT machinery and arrestin-related
RT proteins: implications for PPXY-dependent budding.";
RL J. Virol. 85:3546-3556(2011).
CC -!- SUBUNIT: Interacts with WWP1 (via WW domains).
CC {ECO:0000269|PubMed:21191027}.
CC -!- INTERACTION:
CC Q8TBH0; O95208-2: EPN2; NbExp=3; IntAct=EBI-12191751, EBI-12135243;
CC Q8TBH0; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-12191751, EBI-527853;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TBH0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBH0-2; Sequence=VSP_019544;
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; AK127940; BAC87200.1; -; mRNA.
DR EMBL; AK314657; BAG37216.1; -; mRNA.
DR EMBL; AF193051; AAG22479.1; -; mRNA.
DR EMBL; CH471106; EAW84650.1; -; Genomic_DNA.
DR EMBL; BC022516; AAH22516.1; -; mRNA.
DR EMBL; AF131826; AAD20053.1; -; mRNA.
DR CCDS; CCDS12370.1; -. [Q8TBH0-1]
DR CCDS; CCDS32956.1; -. [Q8TBH0-2]
DR RefSeq; NP_001020775.1; NM_001025604.2. [Q8TBH0-2]
DR RefSeq; NP_001273755.1; NM_001286826.1.
DR RefSeq; NP_056498.1; NM_015683.1. [Q8TBH0-1]
DR AlphaFoldDB; Q8TBH0; -.
DR SMR; Q8TBH0; -.
DR BioGRID; 118004; 5.
DR IntAct; Q8TBH0; 2.
DR STRING; 9606.ENSP00000222250; -.
DR iPTMnet; Q8TBH0; -.
DR PhosphoSitePlus; Q8TBH0; -.
DR BioMuta; ARRDC2; -.
DR DMDM; 109940307; -.
DR EPD; Q8TBH0; -.
DR jPOST; Q8TBH0; -.
DR MassIVE; Q8TBH0; -.
DR PaxDb; Q8TBH0; -.
DR PeptideAtlas; Q8TBH0; -.
DR PRIDE; Q8TBH0; -.
DR ProteomicsDB; 74017; -. [Q8TBH0-1]
DR ProteomicsDB; 74018; -. [Q8TBH0-2]
DR Antibodypedia; 58020; 99 antibodies from 22 providers.
DR DNASU; 27106; -.
DR Ensembl; ENST00000222250.5; ENSP00000222250.3; ENSG00000105643.11. [Q8TBH0-1]
DR Ensembl; ENST00000379656.7; ENSP00000368977.1; ENSG00000105643.11. [Q8TBH0-2]
DR GeneID; 27106; -.
DR KEGG; hsa:27106; -.
DR MANE-Select; ENST00000222250.5; ENSP00000222250.3; NM_015683.2; NP_056498.1.
DR UCSC; uc002nhu.4; human. [Q8TBH0-1]
DR CTD; 27106; -.
DR DisGeNET; 27106; -.
DR GeneCards; ARRDC2; -.
DR HGNC; HGNC:25225; ARRDC2.
DR HPA; ENSG00000105643; Tissue enhanced (skeletal).
DR neXtProt; NX_Q8TBH0; -.
DR OpenTargets; ENSG00000105643; -.
DR PharmGKB; PA134945141; -.
DR VEuPathDB; HostDB:ENSG00000105643; -.
DR eggNOG; KOG3780; Eukaryota.
DR GeneTree; ENSGT00940000159994; -.
DR HOGENOM; CLU_039221_1_1_1; -.
DR InParanoid; Q8TBH0; -.
DR OMA; DCPPVYS; -.
DR PhylomeDB; Q8TBH0; -.
DR TreeFam; TF313650; -.
DR PathwayCommons; Q8TBH0; -.
DR SignaLink; Q8TBH0; -.
DR BioGRID-ORCS; 27106; 20 hits in 1080 CRISPR screens.
DR ChiTaRS; ARRDC2; human.
DR GenomeRNAi; 27106; -.
DR Pharos; Q8TBH0; Tbio.
DR PRO; PR:Q8TBH0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TBH0; protein.
DR Bgee; ENSG00000105643; Expressed in right lung and 171 other tissues.
DR ExpressionAtlas; Q8TBH0; baseline and differential.
DR Genevisible; Q8TBH0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; SSF81296; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..407
FT /note="Arrestin domain-containing protein 2"
FT /id="PRO_0000244347"
FT VAR_SEQ 1..91
FT /note="MLFDKVKAFSVQLDGATAGVEPVFSGGQAVAGRVLLELSSAARVGALRLRAR
FT GRAHVHWTESRSAGSSTAYTQSYSERVEVVSHRATLLAP -> MRSGGVRSFALELARG
FT PGGAYRGGERLCGRVLLEAAAPLRVRALEVKARGGAATHWLEGRSVGVNAVSSDYAAAE
FT TYLRRRQLLLR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019544"
FT VARIANT 181
FT /note="R -> H (in dbSNP:rs17852061)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026895"
FT VARIANT 192
FT /note="R -> H (in dbSNP:rs17852062)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026896"
FT VARIANT 244
FT /note="A -> T (in dbSNP:rs8110271)"
FT /id="VAR_026897"
FT VARIANT 396
FT /note="L -> P (in dbSNP:rs7259041)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026898"
SQ SEQUENCE 407 AA; 44379 MW; AC11194410C31BD8 CRC64;
MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR ARGRAHVHWT
ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP PGRHEFLFSF QLPPTLVTSF
EGKHGSVRYC IKATLHRPWV PARRARKVFT VIEPVDINTP ALLAPQAGAR EKVARSWYCN
RGLVSLSAKI DRKGYTPGEV IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV
ASLAGEPVGP GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL
VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE EAALGQSPFP
LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM RPRCMTC
