ID   OAZ_ASHGO               Reviewed;         255 AA.
AC   Q751H1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Ornithine decarboxylase antizyme;
GN   Name=OAZ1; OrderedLocusNames=AGL265W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis in response to increased intracellular polyamine levels.
CC       Binds to ODC monomers, inhibiting the assembly of the functional ODC
CC       homodimer, and targets the monomers for ubiquitin-independent
CC       proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:Q02803}.
CC   -!- SUBUNIT: Interacts with ODC and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:Q02803}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ala-63
CC         and Asp-64. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q751H1-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54226.2; -; Genomic_DNA.
DR   RefSeq; NP_986402.2; NM_211464.3. [Q751H1-1]
DR   AlphaFoldDB; Q751H1; -.
DR   SMR; Q751H1; -.
DR   STRING; 33169.AAS54226; -.
DR   EnsemblFungi; AAS54226; AAS54226; AGOS_AGL265W. [Q751H1-1]
DR   GeneID; 4622695; -.
DR   KEGG; ago:AGOS_AGL265W; -.
DR   eggNOG; ENOG502RZPH; Eukaryota.
DR   HOGENOM; CLU_087076_0_0_1; -.
DR   InParanoid; Q751H1; -.
DR   OMA; DFQQIGD; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR002993; ODC_AZ.
DR   Pfam; PF02100; ODC_AZ; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ribosomal frameshifting.
FT   CHAIN           1..255
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220866"
SQ   SEQUENCE   255 AA;  29498 MW;  786235AF3DD469FF CRC64;
     MMEQLRKKEQ HIAKVVGECS TQGAVSVSFS TVQLAKGTCL EKLRPWMLRY RCSSRTGYAE
     WLADRAGAQS VRMAELLELY WDLIAVVEAR FAVVPSEVEE ERFYRRFQAH VVRRVGRRIT
     CTARGRACAE DKYPDFQQIG DMYGAVGDEQ GVHLYKWVQS SRRLLVLMDE RAAGRVDLKR
     WLVMMMELVD GARMLRGCQA LQVYVSREDL VNVKDLLKNL NWIGGELVQN VGDRWSDDEA
     MVWSDERYVV IRFDC