ID   ARRD2_MOUSE             Reviewed;         407 AA.
AC   Q9D668; Q3UVK8; Q3UXC6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Arrestin domain-containing protein 2;
GN   Name=Arrdc2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg, and Skin;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with WWP1 (via WW domains).
CC       {ECO:0000250|UniProtKB:Q8TBH0}.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; AK014582; BAB29443.1; -; mRNA.
DR   EMBL; AK135740; BAE22637.1; -; mRNA.
DR   EMBL; AK137175; BAE23261.1; -; mRNA.
DR   EMBL; BC036384; AAH36384.1; -; mRNA.
DR   CCDS; CCDS40376.1; -.
DR   RefSeq; NP_081836.1; NM_027560.1.
DR   AlphaFoldDB; Q9D668; -.
DR   SMR; Q9D668; -.
DR   STRING; 10090.ENSMUSP00000002989; -.
DR   PhosphoSitePlus; Q9D668; -.
DR   PaxDb; Q9D668; -.
DR   PRIDE; Q9D668; -.
DR   ProteomicsDB; 283175; -.
DR   Antibodypedia; 58020; 99 antibodies from 22 providers.
DR   DNASU; 70807; -.
DR   Ensembl; ENSMUST00000002989; ENSMUSP00000002989; ENSMUSG00000002910.
DR   GeneID; 70807; -.
DR   KEGG; mmu:70807; -.
DR   UCSC; uc009mbt.1; mouse.
DR   CTD; 27106; -.
DR   MGI; MGI:1918057; Arrdc2.
DR   VEuPathDB; HostDB:ENSMUSG00000002910; -.
DR   eggNOG; KOG3780; Eukaryota.
DR   GeneTree; ENSGT00940000159994; -.
DR   HOGENOM; CLU_039221_1_1_1; -.
DR   InParanoid; Q9D668; -.
DR   OMA; DCPPVYS; -.
DR   OrthoDB; 430902at2759; -.
DR   PhylomeDB; Q9D668; -.
DR   TreeFam; TF313650; -.
DR   BioGRID-ORCS; 70807; 4 hits in 72 CRISPR screens.
DR   ChiTaRS; Arrdc2; mouse.
DR   PRO; PR:Q9D668; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9D668; protein.
DR   Bgee; ENSMUSG00000002910; Expressed in hindlimb stylopod muscle and 60 other tissues.
DR   ExpressionAtlas; Q9D668; baseline and differential.
DR   Genevisible; Q9D668; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..407
FT                   /note="Arrestin domain-containing protein 2"
FT                   /id="PRO_0000244348"
FT   CONFLICT        227
FT                   /note="F -> L (in Ref. 1; BAE23261)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        261
FT                   /note="L -> Q (in Ref. 1; BAE22637)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   407 AA;  44259 MW;  22F0BC3BADDCA3DF CRC64;
     MLFDKVKAFV VEIDGARTGT EPVFHGGQAV AGRVLLELAG AARVGALRLR ARGRARAHWT
     ESRSAGSSTA YTQSYSERVE VVNHRATLLA PDSGDIATLP AGRHEFPFSF QLPISLVTSF
     EGKHGSVRYS IKATLHRPWV PARCARKVFT VIEPVDINTP ALLEPQAGAR EKVARSWYCT
     RGLVSLSAKI DRKGYTPGEV IPIFAEIDNG STRAVQPRAA LVQTQTFMAR GARKQKRAVV
     ASVDGEPVGP NRRALWPGRA LRIPPVGPSI LQCRVLSVDY SLKVFVDIPG SSKLLLELPL
     VIGTVPLHPL GSRSASVGSR ASFLQDWGLC TMMDRPEAPP EYSEVVRESQ LVCASPGPSS
     LLHDLGVTTE GPYFACLQEF RYCPPPLYSE EDPNPPSEAV RPRCMTC