ID   OAZ_DROVI               Reviewed;         130 AA.
AC   O44535;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ornithine decarboxylase antizyme;
DE            Short=ODC-Az;
DE   AltName: Full=Protein gutfeeling;
DE   Flags: Fragment;
GN   Name=Oda; Synonyms=guf;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9488472; DOI=10.1128/mcb.18.3.1553;
RA   Ivanov I.P., Simin K., Letsou A., Atkins J.F., Gesteland R.F.;
RT   "The Drosophila gene for antizyme requires ribosomal frameshifting for
RT   expression and contains an intronic gene for snRNP Sm D3 on the opposite
RT   strand.";
RL   Mol. Cell. Biol. 18:1553-1561(1998).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-1
CC         and Asp-2. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=O44535-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF038872; AAB95482.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; O44535; -.
DR   SMR; O44535; -.
DR   ChiTaRS; Oda; fly.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Ribosomal frameshifting.
FT   CHAIN           <1..>130
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220863"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         130
SQ   SEQUENCE   130 AA;  14126 MW;  2A15EB40F22F6DB4 CRC64;
     SDVPVHHRTD HDRASLLTGS SRKSSVDSAG GSLFEASSRA SSPSSSSSSE CSDTESHDIH
     SLCSEDDCQE VLRQILQHDQ PVHISIKLHV TEDQSTNWMS ILNPNNNILY VAFPTDFAPA
     GSKETFTSLL