ID   OAZ_ONCVO               Reviewed;         145 AA.
AC   Q9NHZ5;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Ornithine decarboxylase antizyme;
DE            Short=ODC-Az;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10775274; DOI=10.1093/emboj/19.8.1907;
RA   Ivanov I.P., Matsufuji S., Murakami Y., Gesteland R.F., Atkins J.F.;
RT   "Conservation of polyamine regulation by translational frameshifting from
RT   yeast to mammals.";
RL   EMBO J. 19:1907-1917(2000).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-28
CC         and Asp-29. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q9NHZ5-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF217279; AAF68270.1; -; mRNA.
DR   AlphaFoldDB; Q9NHZ5; -.
DR   SMR; Q9NHZ5; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IEA:InterPro.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ribosomal frameshifting.
FT   CHAIN           1..145
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220864"
SQ   SEQUENCE   145 AA;  16200 MW;  08F1FB94766BEF63 CRC64;
     MSKLAVSSSF SLLCGNCKRG HVGLECYSDV PTNNLLSNEH LHSLESFVNE VSSEWCCHLV
     DGNTLAIFLP FDQSTWNLSK GAFVSLLEFC EDNLPIKRIL LCLNKINVDE TVVSCFKYLG
     FSPLHPHLYP SCIDSQGVFV MVYSM