ID   OAZ_PRIPA               Reviewed;         142 AA.
AC   Q9NHZ4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Ornithine decarboxylase antizyme;
DE            Short=ODC-Az;
OS   Pristionchus pacificus (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae;
OC   Pristionchus.
OX   NCBI_TaxID=54126;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10775274; DOI=10.1093/emboj/19.8.1907;
RA   Ivanov I.P., Matsufuji S., Murakami Y., Gesteland R.F., Atkins J.F.;
RT   "Conservation of polyamine regulation by translational frameshifting from
RT   yeast to mammals.";
RL   EMBO J. 19:1907-1917(2000).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimer, and targets the monomers for ubiquitin-
CC       independent proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:P54368}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:P54368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-28
CC         and Asp-29. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q9NHZ4-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF217280; AAF68271.1; -; mRNA.
DR   AlphaFoldDB; Q9NHZ4; -.
DR   SMR; Q9NHZ4; -.
DR   STRING; 54126.Q9NHZ4; -.
DR   Proteomes; UP000005239; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ribosomal frameshifting.
FT   CHAIN           1..142
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220865"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   142 AA;  15692 MW;  EA38462E9B3A0621 CRC64;
     MSSSIVLSNN NSNSNSMSMI GQSPPCCSDV PNTPASEEMT RMVKNVVASW EWVPLGKDKV
     GIIIPADQDH RQVHKSRFVD LLEFCDETMK VKEVIAVFGR ADLTVAAGFP RTLRYVGFRV
     VAPENFPPTL DATTHFAMTY VV