ID   OAZ_SCHJP               Reviewed;         226 AA.
AC   Q9HFU9;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Ornithine decarboxylase antizyme;
DE            Short=ODC-Az;
GN   Name=spa1;
OS   Schizosaccharomyces japonicus (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4897;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10954585; DOI=10.1093/nar/28.17.3185;
RA   Ivanov I.P., Gesteland R.F., Atkins J.F.;
RT   "Antizyme expression: a subversion of triplet decoding, which is remarkably
RT   conserved by evolution, is a sensor for an autoregulatory circuit.";
RL   Nucleic Acids Res. 28:3185-3196(2000).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis in response to increased intracellular polyamine levels.
CC       Binds to ODC monomers, inhibiting the assembly of the functional ODC
CC       homodimer, and targets the monomers for ubiquitin-independent
CC       proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:Q02803}.
CC   -!- SUBUNIT: Interacts with ODC and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:Q02803}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-60
CC         and Glu-61. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q9HFU9-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF291572; AAG16232.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HFU9; -.
DR   VEuPathDB; FungiDB:SJAG_04546; -.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IEA:InterPro.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..226
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220868"
SQ   SEQUENCE   226 AA;  25805 MW;  3BED7A88667B4C54 CRC64;
     MAFRNPIYQL SNTEDLNLDI INAPSLENSR RSSATLAVCT TEDSKFLYGT TPSGGAEWCS
     EGINSVRPSK RLLRRRRHVP RWISDSFRTC LPKSSGNLKE QALQPSLDRN PCRNGQADEA
     LRNKRIGIAE PSNYWHGIIE ETYDEHHQRQ RNLHLIPENW QDVNLKNGLV AIIDLATDHL
     QCSKLIIYVD KHLPNLPYLV KSFHWVGFEP IAHPNCVDHA VFGMDL