ID   OAZ_SCHOT               Reviewed;         224 AA.
AC   Q9HFU8;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Ornithine decarboxylase antizyme;
DE            Short=ODC-Az;
GN   Name=spa1;
OS   Schizosaccharomyces octosporus (Fission yeast) (Octosporomyces octosporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4899;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10954585; DOI=10.1093/nar/28.17.3185;
RA   Ivanov I.P., Gesteland R.F., Atkins J.F.;
RT   "Antizyme expression: a subversion of triplet decoding, which is remarkably
RT   conserved by evolution, is a sensor for an autoregulatory circuit.";
RL   Nucleic Acids Res. 28:3185-3196(2000).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis in response to increased intracellular polyamine levels.
CC       Binds to ODC monomers, inhibiting the assembly of the functional ODC
CC       homodimer, and targets the monomers for ubiquitin-independent
CC       proteolytic destruction by the 26S proteasome.
CC       {ECO:0000250|UniProtKB:Q02803}.
CC   -!- SUBUNIT: Interacts with ODC and thereby sterically blocks ODC
CC       homodimerization. {ECO:0000250|UniProtKB:Q02803}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-65
CC         and Glu-66. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=Q9HFU8-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF291573; AAG16233.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HFU8; -.
DR   VEuPathDB; FungiDB:SOCG_04402; -.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IEA:InterPro.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; PTHR10279; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..224
FT                   /note="Ornithine decarboxylase antizyme"
FT                   /id="PRO_0000220869"
SQ   SEQUENCE   224 AA;  25672 MW;  8CB7F30E653762D1 CRC64;
     MAFRNPMYQL SNVDDIDSEV LNSRFLSETK DDGFSRRRTT LAVCATKKDL YLYGTTPAGG
     AEWCSEVLER TRPRIAHKRQ RRRHVPRWIS DSFRTCLPSP SGKWKEQTAN EGEGRVKSSW
     LAACDERIGI AEPTNYWHGI VRTEDDSSKT LYLIPETWED VHLKEGFVAI IDLAAERLQC
     SKLILFVDKN LSALSYLVKS LHWVGFEPVP HLDCVDHVLF GMEL