OB10_DROME
ID OB10_DROME Reviewed; 155 AA.
AC Q27377; Q3LB26; Q9VVD1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Putative odorant-binding protein A10;
DE AltName: Full=Antennal protein 10;
DE AltName: Full=OS-D protein;
DE Flags: Precursor;
GN Name=a10; Synonyms=OS-D; ORFNames=CG6642;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S; TISSUE=Antenna;
RX PubMed=7545907; DOI=10.1016/0896-6273(94)90150-3;
RA Pikielny C.W., Hasan G., Rouyer F., Rosbash M.;
RT "Members of a family of Drosophila putative odorant-binding proteins are
RT expressed in different subsets of olfactory hairs.";
RL Neuron 12:35-49(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CS-5; TISSUE=Antenna;
RX PubMed=8206941; DOI=10.1016/s0021-9258(17)34013-9;
RA McKenna M.P., Hekmat-Scafe D.S., Gaines P., Carlson J.R.;
RT "Putative Drosophila pheromone-binding proteins expressed in a subregion of
RT the olfactory system.";
RL J. Biol. Chem. 269:16340-16347(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16581978; DOI=10.1093/chemse/bjj050;
RA Zhou J.-J., Kan Y., Antoniw J., Pickett J.A., Field L.M.;
RT "Genome and EST analyses and expression of a gene family with putative
RT functions in insect chemoreception.";
RL Chem. Senses 31:453-465(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Antenna. In the third antennal segment. Expressed
CC in sencilla coeloconica.
CC -!- DEVELOPMENTAL STAGE: Expressed in adult but not in larval olfactory
CC organs.
CC -!- SIMILARITY: Belongs to the insect A10/OS-D protein family.
CC {ECO:0000305}.
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DR EMBL; U05244; AAC46473.1; -; mRNA.
DR EMBL; U02546; AAA21358.1; -; mRNA.
DR EMBL; AJ973480; CAJ01527.1; -; mRNA.
DR EMBL; AE014296; AAF49381.1; -; Genomic_DNA.
DR EMBL; BT025814; ABF85714.1; -; mRNA.
DR RefSeq; NP_524121.2; NM_079397.3.
DR AlphaFoldDB; Q27377; -.
DR SMR; Q27377; -.
DR BioGRID; 65201; 1.
DR IntAct; Q27377; 1.
DR STRING; 7227.FBpp0075050; -.
DR PaxDb; Q27377; -.
DR DNASU; 39906; -.
DR EnsemblMetazoa; FBtr0075290; FBpp0075050; FBgn0011293.
DR GeneID; 39906; -.
DR KEGG; dme:Dmel_CG6642; -.
DR CTD; 39906; -.
DR FlyBase; FBgn0011293; a10.
DR VEuPathDB; VectorBase:FBgn0011293; -.
DR eggNOG; ENOG502S48A; Eukaryota.
DR GeneTree; ENSGT00390000011556; -.
DR HOGENOM; CLU_1564538_0_0_1; -.
DR InParanoid; Q27377; -.
DR OMA; QVEGLPH; -.
DR OrthoDB; 1553421at2759; -.
DR PhylomeDB; Q27377; -.
DR BioGRID-ORCS; 39906; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39906; -.
DR PRO; PR:Q27377; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0011293; Expressed in head capsule and 7 other tissues.
DR ExpressionAtlas; Q27377; baseline and differential.
DR Genevisible; Q27377; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR Gene3D; 1.10.2080.10; -; 1.
DR InterPro; IPR005055; A10/PebIII.
DR InterPro; IPR036682; OS_D_A10/PebIII_sf.
DR PANTHER; PTHR11257; PTHR11257; 1.
DR Pfam; PF03392; OS-D; 1.
DR SUPFAM; SSF100910; SSF100910; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..155
FT /note="Putative odorant-binding protein A10"
FT /id="PRO_0000021874"
FT CONFLICT 13
FT /note="V -> F (in Ref. 1; AAC46473 and 2; AAA21358)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 155 AA; 17780 MW; A10345771C338261 CRC64;
MGQPGFRRAI GHVSLVVALM CTTCFQVEGL PHPPATSPSP MMERMVEQAY DDKFDNVDLD
EILNQERLLI NYIKCLEGTG PCTPDAKMLK EILPDAIQTD CTKCTEKQRY GAEKVTRHLI
DNRPTDWERL EKIYDPEGTY RIKYQEMKSK ANEEP
