OB19A_DROME
ID OB19A_DROME Reviewed; 146 AA.
AC Q9VR94; C9QNY2; G2J5W2; Q8IQ33;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=General odorant-binding protein 19a;
DE Flags: Precursor;
GN Name=Obp19a; ORFNames=CG11748;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11729153; DOI=10.1093/genetics/159.3.1059;
RA Galindo K., Smith D.P.;
RT "A large family of divergent Drosophila odorant-binding proteins expressed
RT in gustatory and olfactory sensilla.";
RL Genetics 159:1059-1072(2001).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in adult olfactory system. Expressed
CC exclusively in a subset of chemosensory sensilla on the third antennal
CC segment. {ECO:0000269|PubMed:11729153}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACX30026.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=ACX30026.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AEM72515.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAF50910.2; -; Genomic_DNA.
DR EMBL; BT099864; ACX30026.1; ALT_SEQ; mRNA.
DR EMBL; BT128819; AEM72515.1; ALT_INIT; mRNA.
DR RefSeq; NP_728338.2; NM_167700.3.
DR AlphaFoldDB; Q9VR94; -.
DR SMR; Q9VR94; -.
DR STRING; 7227.FBpp0297995; -.
DR PaxDb; Q9VR94; -.
DR EnsemblMetazoa; FBtr0307166; FBpp0297995; FBgn0031109.
DR GeneID; 33037; -.
DR KEGG; dme:Dmel_CG11748; -.
DR CTD; 33037; -.
DR FlyBase; FBgn0031109; Obp19a.
DR VEuPathDB; VectorBase:FBgn0031109; -.
DR eggNOG; ENOG502SA47; Eukaryota.
DR GeneTree; ENSGT00940000176403; -.
DR HOGENOM; CLU_107288_0_0_1; -.
DR InParanoid; Q9VR94; -.
DR OMA; EMMQTMK; -.
DR OrthoDB; 1461377at2759; -.
DR PhylomeDB; Q9VR94; -.
DR BioGRID-ORCS; 33037; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33037; -.
DR PRO; PR:Q9VR94; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0031109; Expressed in head capsule and 15 other tissues.
DR ExpressionAtlas; Q9VR94; differential.
DR Genevisible; Q9VR94; DM.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0035275; F:dibutyl phthalate binding; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Secreted;
KW Sensory transduction; Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..146
FT /note="General odorant-binding protein 19a"
FT /id="PRO_0000012568"
FT DISULFID 40..72
FT /evidence="ECO:0000250"
FT DISULFID 68..126
FT /evidence="ECO:0000250"
FT DISULFID 113..135
FT /evidence="ECO:0000250"
SQ SEQUENCE 146 AA; 16323 MW; 4560555AC5E4424C CRC64;
MKFHLLLVCV AISLGPIPQS EAGVTEEQMW SAGKLMRDVC LPKYPKVSVE VADNIRNGDI
PNSKDTNCYI NCILEMMQAI KKGKFQLEST LKQMDIMLPD SYKDEYRKGI NLCKDSTVGL
KNAPNCDPAH ALLSCLKNNI KVFVFP
