ID   ARRD3_BOVIN             Reviewed;         414 AA.
AC   Q0VCA2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Arrestin domain-containing protein 3;
GN   Name=ARRDC3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein that plays a role in regulating cell-surface
CC       expression of adrenergic receptors and probably also other G protein-
CC       coupled receptors. Plays a role in NEDD4-mediated ubiquitination and
CC       endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May
CC       recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein
CC       that does not play a major role in recruiting NEDD4 to ADRB2, but
CC       rather plays a role in a targeting ADRB2 to endosomes.
CC       {ECO:0000250|UniProtKB:Q96B67}.
CC   -!- SUBUNIT: Interacts (via PPxY motifs) with NEDD4 (via WW domains).
CC       Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via
CC       PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH.
CC       {ECO:0000250|UniProtKB:Q96B67}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B67}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q96B67}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q96B67}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q96B67}. Lysosome
CC       {ECO:0000250|UniProtKB:Q96B67}. Endosome
CC       {ECO:0000250|UniProtKB:Q96B67}. Early endosome
CC       {ECO:0000250|UniProtKB:Q96B67}. Note=Associated with plasma membrane,
CC       as well as with endosomes and lysosomes during endocytosis.
CC       {ECO:0000250|UniProtKB:Q96B67}.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; BC120276; AAI20277.1; -; mRNA.
DR   RefSeq; NP_001069725.1; NM_001076257.2.
DR   AlphaFoldDB; Q0VCA2; -.
DR   SMR; Q0VCA2; -.
DR   STRING; 9913.ENSBTAP00000009364; -.
DR   PaxDb; Q0VCA2; -.
DR   PRIDE; Q0VCA2; -.
DR   Ensembl; ENSBTAT00000009364; ENSBTAP00000009364; ENSBTAG00000007116.
DR   GeneID; 541123; -.
DR   KEGG; bta:541123; -.
DR   CTD; 57561; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007116; -.
DR   VGNC; VGNC:26173; ARRDC3.
DR   eggNOG; KOG3780; Eukaryota.
DR   GeneTree; ENSGT00940000155411; -.
DR   HOGENOM; CLU_039221_1_1_1; -.
DR   InParanoid; Q0VCA2; -.
DR   OMA; WFLPVKL; -.
DR   OrthoDB; 817924at2759; -.
DR   TreeFam; TF313650; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000007116; Expressed in myometrium and 106 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031699; F:beta-3 adrenergic receptor binding; IEA:Ensembl.
DR   GO; GO:0060613; P:fat pad development; IEA:Ensembl.
DR   GO; GO:0031649; P:heat generation; IEA:Ensembl.
DR   GO; GO:0071878; P:negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0031651; P:negative regulation of heat generation; IEA:Ensembl.
DR   GO; GO:0090327; P:negative regulation of locomotion involved in locomotory behavior; IEA:Ensembl.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Endosome; Lysosome; Membrane; Reference proteome;
KW   Repeat.
FT   CHAIN           1..414
FT                   /note="Arrestin domain-containing protein 3"
FT                   /id="PRO_0000282340"
FT   REGION          393..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           346..349
FT                   /note="PPxY motif 1"
FT                   /evidence="ECO:0000305"
FT   MOTIF           391..394
FT                   /note="PPxY motif 2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   414 AA;  46370 MW;  EC1714EC0DFB11CA CRC64;
     MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT
     ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFNTIHSGRH EYAFSFELPQ
     TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT
     LYCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM
     KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
     LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLGLSLP ERPEAPPSYA EVVTEEQRRN
     NLAPGSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQPADDRPS CPSR