OB19D_DROME
ID OB19D_DROME Reviewed; 150 AA.
AC P54192; A4V4T7; B3DMN4; Q8MYT1; Q9VR97;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=General odorant-binding protein 19d;
DE AltName: Full=Odorant-binding protein 19d;
DE AltName: Full=Pheromone-binding protein-related protein 2;
DE Short=PBPRP-2;
DE Flags: Precursor;
GN Name=Obp19d; Synonyms=Pbprp2; ORFNames=CG1668;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Antenna;
RX PubMed=7545907; DOI=10.1016/0896-6273(94)90150-3;
RA Pikielny C.W., Hasan G., Rouyer F., Rosbash M.;
RT "Members of a family of Drosophila putative odorant-binding proteins are
RT expressed in different subsets of olfactory hairs.";
RL Neuron 12:35-49(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC P54192; P42325: Nca; NbExp=4; IntAct=EBI-26770067, EBI-149848;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted in the
CC lumen of olfactory hairs. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the antenna, mostly on the anterior
CC surface of the third antennal segment. Also detected in the maxillary
CC palps and in cells at the bases of the taste hairs on the proboscis and
CC internal taste organs of the head. {ECO:0000269|PubMed:7545907}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACD81686.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U05981; AAC46475.1; -; mRNA.
DR EMBL; AE014298; AAF50907.1; -; Genomic_DNA.
DR EMBL; AE014298; AAO41713.1; -; Genomic_DNA.
DR EMBL; AY113621; AAM29626.1; -; mRNA.
DR EMBL; AY118484; AAM49853.1; -; mRNA.
DR EMBL; BT032672; ACD81686.1; ALT_INIT; mRNA.
DR PIR; S65395; S65395.
DR RefSeq; NP_523421.2; NM_078697.3.
DR RefSeq; NP_788940.1; NM_176767.2.
DR AlphaFoldDB; P54192; -.
DR SMR; P54192; -.
DR BioGRID; 59331; 4.
DR IntAct; P54192; 2.
DR STRING; 7227.FBpp0076995; -.
DR PaxDb; P54192; -.
DR DNASU; 33040; -.
DR EnsemblMetazoa; FBtr0077303; FBpp0076995; FBgn0011280.
DR EnsemblMetazoa; FBtr0077304; FBpp0076996; FBgn0011280.
DR GeneID; 33040; -.
DR KEGG; dme:Dmel_CG1668; -.
DR CTD; 33040; -.
DR FlyBase; FBgn0011280; Obp19d.
DR VEuPathDB; VectorBase:FBgn0011280; -.
DR eggNOG; ENOG502T2AN; Eukaryota.
DR GeneTree; ENSGT00520000058998; -.
DR HOGENOM; CLU_148261_0_0_1; -.
DR InParanoid; P54192; -.
DR OMA; ECKAETG; -.
DR OrthoDB; 1320220at2759; -.
DR PhylomeDB; P54192; -.
DR BioGRID-ORCS; 33040; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Obp19d; fly.
DR GenomeRNAi; 33040; -.
DR PRO; PR:P54192; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0011280; Expressed in antenna and 31 other tissues.
DR ExpressionAtlas; P54192; differential.
DR Genevisible; P54192; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0005550; F:pheromone binding; ISS:FlyBase.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..150
FT /note="General odorant-binding protein 19d"
FT /id="PRO_0000012587"
FT DISULFID 41..72
FT /evidence="ECO:0000250"
FT DISULFID 68..126
FT /evidence="ECO:0000250"
FT DISULFID 116..135
FT /evidence="ECO:0000250"
FT CONFLICT 34..35
FT /note="AA -> LL (in Ref. 1; AAC46475)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="C -> S (in Ref. 4; AAM29626)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="K -> R (in Ref. 1; AAC46475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 150 AA; 16782 MW; AEEC364FFA416FA9 CRC64;
MSHLVHLTVL LLVGILCLGA TSAKPHEEIN RDHAAELANE CKAETGATDE DVEQLMSHDL
PERHEAKCLR ACVMKKLQIM DESGKLNKEH AIELVKVMSK HDAEKEDAPA EVVAKCEAIE
TPEDHCDAAF AYEECIYEQM KEHGLELEEH
