OB56A_DROME
ID OB56A_DROME Reviewed; 139 AA.
AC Q9V8Y2; A9QH77; A9QH80; A9QH86; A9QH94; A9QHB8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=General odorant-binding protein 56a;
DE Flags: Precursor;
GN Name=Obp56a; ORFNames=CG11797;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-15; MET-88 AND SER-120.
RC STRAIN=301A, 303A, 304A, 306A, 307A, 313A, 315A, 318A, 319A, 322A, 324A,
RC 332A, 335A, 336A, 350A, 357A, 358A, 359A, 361A, 362A, 375A, 390A, 397A,
RC 399A, 705A, 707A, 732A, 734A, 735A, 736A, 737A, 740A, 765A, 773A, 774A,
RC 786A, 787A, 797A, 799A, 808A, 813A, 820A, 822A, 832A, 838A, 852A, 859A,
RC 868A, 907A, and 911A;
RX PubMed=17720903; DOI=10.1534/genetics.107.079731;
RA Wang P., Lyman R.F., Shabalina S.A., Mackay T.F.C., Anholt R.R.H.;
RT "Association of polymorphisms in odorant-binding protein genes with
RT variation in olfactory response to benzaldehyde in Drosophila.";
RL Genetics 177:1655-1665(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11729153; DOI=10.1093/genetics/159.3.1059;
RA Galindo K., Smith D.P.;
RT "A large family of divergent Drosophila odorant-binding proteins expressed
RT in gustatory and olfactory sensilla.";
RL Genetics 159:1059-1072(2001).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=12505997; DOI=10.1242/dev.00293;
RA Butler M.J., Jacobsen T.L., Cain D.M., Jarman M.G., Hubank M.,
RA Whittle J.R.S., Phillips R., Simcox A.;
RT "Discovery of genes with highly restricted expression patterns in the
RT Drosophila wing disc using DNA oligonucleotide microarrays.";
RL Development 130:659-670(2003).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in ventral pits of larvae. In adults, it
CC is not specifically expressed in chemosensory organs. Also expressed in
CC stalk cells at the proximal tip of the wing disk.
CC {ECO:0000269|PubMed:11729153, ECO:0000269|PubMed:12505997}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR EMBL; EU088428; ABW77763.1; -; Genomic_DNA.
DR EMBL; EU088429; ABW77764.1; -; Genomic_DNA.
DR EMBL; EU088430; ABW77765.1; -; Genomic_DNA.
DR EMBL; EU088431; ABW77766.1; -; Genomic_DNA.
DR EMBL; EU088432; ABW77767.1; -; Genomic_DNA.
DR EMBL; EU088433; ABW77768.1; -; Genomic_DNA.
DR EMBL; EU088434; ABW77769.1; -; Genomic_DNA.
DR EMBL; EU088435; ABW77770.1; -; Genomic_DNA.
DR EMBL; EU088436; ABW77771.1; -; Genomic_DNA.
DR EMBL; EU088437; ABW77772.1; -; Genomic_DNA.
DR EMBL; EU088438; ABW77773.1; -; Genomic_DNA.
DR EMBL; EU088439; ABW77774.1; -; Genomic_DNA.
DR EMBL; EU088440; ABW77775.1; -; Genomic_DNA.
DR EMBL; EU088441; ABW77776.1; -; Genomic_DNA.
DR EMBL; EU088442; ABW77777.1; -; Genomic_DNA.
DR EMBL; EU088443; ABW77778.1; -; Genomic_DNA.
DR EMBL; EU088444; ABW77779.1; -; Genomic_DNA.
DR EMBL; EU088445; ABW77780.1; -; Genomic_DNA.
DR EMBL; EU088446; ABW77781.1; -; Genomic_DNA.
DR EMBL; EU088447; ABW77782.1; -; Genomic_DNA.
DR EMBL; EU088448; ABW77783.1; -; Genomic_DNA.
DR EMBL; EU088449; ABW77784.1; -; Genomic_DNA.
DR EMBL; EU088450; ABW77785.1; -; Genomic_DNA.
DR EMBL; EU088451; ABW77786.1; -; Genomic_DNA.
DR EMBL; EU088452; ABW77787.1; -; Genomic_DNA.
DR EMBL; EU088453; ABW77788.1; -; Genomic_DNA.
DR EMBL; EU088454; ABW77789.1; -; Genomic_DNA.
DR EMBL; EU088455; ABW77790.1; -; Genomic_DNA.
DR EMBL; EU088456; ABW77791.1; -; Genomic_DNA.
DR EMBL; EU088457; ABW77792.1; -; Genomic_DNA.
DR EMBL; EU088458; ABW77793.1; -; Genomic_DNA.
DR EMBL; EU088459; ABW77794.1; -; Genomic_DNA.
DR EMBL; EU088460; ABW77795.1; -; Genomic_DNA.
DR EMBL; EU088461; ABW77796.1; -; Genomic_DNA.
DR EMBL; EU088462; ABW77797.1; -; Genomic_DNA.
DR EMBL; EU088463; ABW77798.1; -; Genomic_DNA.
DR EMBL; EU088464; ABW77799.1; -; Genomic_DNA.
DR EMBL; EU088465; ABW77800.1; -; Genomic_DNA.
DR EMBL; EU088466; ABW77801.1; -; Genomic_DNA.
DR EMBL; EU088467; ABW77802.1; -; Genomic_DNA.
DR EMBL; EU088468; ABW77803.1; -; Genomic_DNA.
DR EMBL; EU088469; ABW77804.1; -; Genomic_DNA.
DR EMBL; EU088470; ABW77805.1; -; Genomic_DNA.
DR EMBL; EU088471; ABW77806.1; -; Genomic_DNA.
DR EMBL; EU088472; ABW77807.1; -; Genomic_DNA.
DR EMBL; EU088473; ABW77808.1; -; Genomic_DNA.
DR EMBL; EU088474; ABW77809.1; -; Genomic_DNA.
DR EMBL; EU088475; ABW77810.1; -; Genomic_DNA.
DR EMBL; EU088476; ABW77811.1; -; Genomic_DNA.
DR EMBL; EU088477; ABW77812.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF57522.1; -; Genomic_DNA.
DR EMBL; AY071723; AAL49345.1; -; mRNA.
DR EMBL; AY113487; AAM29492.1; -; mRNA.
DR RefSeq; NP_611442.1; NM_137598.3.
DR AlphaFoldDB; Q9V8Y2; -.
DR SMR; Q9V8Y2; -.
DR BioGRID; 62920; 1.
DR IntAct; Q9V8Y2; 5.
DR STRING; 7227.FBpp0085672; -.
DR GlyGen; Q9V8Y2; 1 site.
DR PaxDb; Q9V8Y2; -.
DR DNASU; 37264; -.
DR EnsemblMetazoa; FBtr0086476; FBpp0085672; FBgn0034468.
DR GeneID; 37264; -.
DR KEGG; dme:Dmel_CG11797; -.
DR CTD; 37264; -.
DR FlyBase; FBgn0034468; Obp56a.
DR VEuPathDB; VectorBase:FBgn0034468; -.
DR eggNOG; ENOG502TCE1; Eukaryota.
DR HOGENOM; CLU_107288_3_2_1; -.
DR InParanoid; Q9V8Y2; -.
DR OMA; NIKCFAN; -.
DR OrthoDB; 1371933at2759; -.
DR PhylomeDB; Q9V8Y2; -.
DR BioGRID-ORCS; 37264; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Obp56a; fly.
DR GenomeRNAi; 37264; -.
DR PRO; PR:Q9V8Y2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034468; Expressed in embryonic head epidermis (Drosophila) and 28 other tissues.
DR ExpressionAtlas; Q9V8Y2; baseline and differential.
DR Genevisible; Q9V8Y2; DM.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEP:UniProtKB.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Olfaction; Reference proteome; Secreted;
KW Sensory transduction; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..139
FT /note="General odorant-binding protein 56a"
FT /id="PRO_0000012569"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 39..71
FT /evidence="ECO:0000250"
FT DISULFID 67..118
FT /evidence="ECO:0000250"
FT DISULFID 109..127
FT /evidence="ECO:0000250"
FT VARIANT 15
FT /note="T -> A (in strain: 304A, 319A, 375A, 773A, 774A,
FT 813A, 852A and 859A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 88
FT /note="V -> M (in strain: 301A, 306A, 313A, 315A, 318A,
FT 322A, 324A, 332A, 357A, 390A, 399A, 732A, 735A, 736A, 737A,
FT 797A, 799A, 808A, 820A, 822A, 838A and 868A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 120
FT /note="T -> S (in strain: 907A)"
FT /evidence="ECO:0000269|PubMed:17720903"
SQ SEQUENCE 139 AA; 15403 MW; 4B7D47070556EA75 CRC64;
MNSYFVIALS ALFVTLAVGS SLNLSDEQKD LAKQHREQCA EEVKLTEEEK AKVNAKDFNN
PTENIKCFAN CFFEKVGTLK DGELQESVVL EKLGALIGEE KTKAALEKCR TIKGENKCDT
ASKLYDCFES FKPAPEAKA
