OB56D_DROME
ID OB56D_DROME Reviewed; 131 AA.
AC Q8SY61; Q9V8Y4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=General odorant-binding protein 56d;
DE Flags: Precursor;
GN Name=Obp56d; ORFNames=CG11218;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11729153; DOI=10.1093/genetics/159.3.1059;
RA Galindo K., Smith D.P.;
RT "A large family of divergent Drosophila odorant-binding proteins expressed
RT in gustatory and olfactory sensilla.";
RL Genetics 159:1059-1072(2001).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=12727233; DOI=10.1016/s0006-291x(03)00683-1;
RA Vierstraete E., Cerstiaens A., Baggerman G., Van den Bergh G., De Loof A.,
RA Schoofs L.;
RT "Proteomics in Drosophila melanogaster: first 2D database of larval
RT hemolymph proteins.";
RL Biochem. Biophys. Res. Commun. 304:831-838(2003).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=12505997; DOI=10.1242/dev.00293;
RA Butler M.J., Jacobsen T.L., Cain D.M., Jarman M.G., Hubank M.,
RA Whittle J.R.S., Phillips R., Simcox A.;
RT "Discovery of genes with highly restricted expression patterns in the
RT Drosophila wing disc using DNA oligonucleotide microarrays.";
RL Development 130:659-670(2003).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Exclusively or primarily restricted to the
CC olfactory system. Expressed in all olfactory sensilla including
CC antenna, maxillary palp, proboscis, other adult chemosensory and larval
CC chemosensory organ. Also expressed in the wing and tarsal gustatory
CC sensilla and dorsal organ. Expressed in larval hemolymph.
CC {ECO:0000269|PubMed:11729153, ECO:0000269|PubMed:12505997}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57520.1; -; Genomic_DNA.
DR EMBL; AY071765; AAL49387.1; -; mRNA.
DR EMBL; AY113425; AAM29430.1; -; mRNA.
DR RefSeq; NP_001286619.1; NM_001299690.1.
DR RefSeq; NP_611444.2; NM_137600.3.
DR AlphaFoldDB; Q8SY61; -.
DR SMR; Q8SY61; -.
DR BioGRID; 62922; 21.
DR IntAct; Q8SY61; 1.
DR STRING; 7227.FBpp0085673; -.
DR PaxDb; Q8SY61; -.
DR PRIDE; Q8SY61; -.
DR DNASU; 37266; -.
DR EnsemblMetazoa; FBtr0086477; FBpp0085673; FBgn0034470.
DR EnsemblMetazoa; FBtr0345676; FBpp0311727; FBgn0034470.
DR GeneID; 37266; -.
DR KEGG; dme:Dmel_CG11218; -.
DR CTD; 37266; -.
DR FlyBase; FBgn0034470; Obp56d.
DR VEuPathDB; VectorBase:FBgn0034470; -.
DR eggNOG; ENOG502SC5Y; Eukaryota.
DR GeneTree; ENSGT00940000176644; -.
DR HOGENOM; CLU_107288_3_2_1; -.
DR InParanoid; Q8SY61; -.
DR OMA; DKCDTAY; -.
DR OrthoDB; 1371933at2759; -.
DR PhylomeDB; Q8SY61; -.
DR BioGRID-ORCS; 37266; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37266; -.
DR PRO; PR:Q8SY61; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034470; Expressed in adult hindgut (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q8SY61; baseline and differential.
DR Genevisible; Q8SY61; DM.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEP:UniProtKB.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Olfaction; Reference proteome; Secreted;
KW Sensory transduction; Signal; Transport.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..131
FT /note="General odorant-binding protein 56d"
FT /id="PRO_0000012570"
FT DISULFID 35..67
FT /evidence="ECO:0000250"
FT DISULFID 63..114
FT /evidence="ECO:0000250"
FT DISULFID 105..123
FT /evidence="ECO:0000250"
FT CONFLICT 32
FT /note="G -> C (in Ref. 3; AAL49387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 14119 MW; 2D694BE48573A6FA CRC64;
MKFLIVLSVI LAISAAELQL SDEQKAVAHA NGALCAQQEG ITKDQAIALR NGNFDDSDPK
VKCFANCFLE KIGFLINGEV QPDVVLAKLG PLAGEDAVKA VQAKCDATKG ADKCDTAYQL
FECYYKNRAH I
