OB56H_DROME
ID OB56H_DROME Reviewed; 134 AA.
AC Q9V8Y9; A0JQ25; A9QI73; A9QI74; A9QI75; A9QI82; A9QI83; A9QI84; A9QI85;
AC A9QI89; A9QI90; A9QI92; A9QI95; A9QIA1; A9QIA2; A9QIB4; A9QIB8; A9QIB9;
AC A9QIC1; Q4V3H6;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=General odorant-binding protein 56h;
DE Flags: Precursor;
GN Name=Obp56h; ORFNames=CG13874;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-7; LEU-13; GLY-22;
RP ASP-39; LEU-44; THR-54; ILE-72; HIS-79; THR-92; HIS-115; ASP-126 AND
RP 127-HIS-LYS-128 DELINS GLN.
RC STRAIN=301A, 303A, 304A, 306A, 307A, 313A, 315A, 318A, 319A, 322A, 324A,
RC 332A, 335A, 336A, 350A, 357A, 358A, 359A, 361A, 362A, 375A, 390A, 397A,
RC 399A, 705A, 707A, 732A, 734A, 735A, 736A, 737A, 740A, 765A, 773A, 774A,
RC 786A, 787A, 797A, 799A, 808A, 813A, 820A, 822A, 832A, 838A, 852A, 859A,
RC 868A, 907A, and 911A;
RX PubMed=17720903; DOI=10.1534/genetics.107.079731;
RA Wang P., Lyman R.F., Shabalina S.A., Mackay T.F.C., Anholt R.R.H.;
RT "Association of polymorphisms in odorant-binding protein genes with
RT variation in olfactory response to benzaldehyde in Drosophila.";
RL Genetics 177:1655-1665(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11729153; DOI=10.1093/genetics/159.3.1059;
RA Galindo K., Smith D.P.;
RT "A large family of divergent Drosophila odorant-binding proteins expressed
RT in gustatory and olfactory sensilla.";
RL Genetics 159:1059-1072(2001).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid (By similarity). May
CC function in both olfactory and gustatory systems. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in both gustatory and olfactory systems
CC of larvae and adults. Expressed in antenna, proboscis and larval
CC chemosensory organ. Expressed in five sensilla on each third antennal
CC segment, in the pharyngeal organs and in the dorsal organ, terminal
CC organ and the ventral pits of the third instar larvae. Also expressed
CC in wing and tarsi. {ECO:0000269|PubMed:11729153}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK56981.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; EU088777; ABW78062.1; -; Genomic_DNA.
DR EMBL; EU088778; ABW78063.1; -; Genomic_DNA.
DR EMBL; EU088779; ABW78064.1; -; Genomic_DNA.
DR EMBL; EU088780; ABW78065.1; -; Genomic_DNA.
DR EMBL; EU088781; ABW78066.1; -; Genomic_DNA.
DR EMBL; EU088782; ABW78067.1; -; Genomic_DNA.
DR EMBL; EU088783; ABW78068.1; -; Genomic_DNA.
DR EMBL; EU088784; ABW78069.1; -; Genomic_DNA.
DR EMBL; EU088785; ABW78070.1; -; Genomic_DNA.
DR EMBL; EU088786; ABW78071.1; -; Genomic_DNA.
DR EMBL; EU088787; ABW78072.1; -; Genomic_DNA.
DR EMBL; EU088788; ABW78073.1; -; Genomic_DNA.
DR EMBL; EU088789; ABW78074.1; -; Genomic_DNA.
DR EMBL; EU088790; ABW78075.1; -; Genomic_DNA.
DR EMBL; EU088791; ABW78076.1; -; Genomic_DNA.
DR EMBL; EU088792; ABW78077.1; -; Genomic_DNA.
DR EMBL; EU088793; ABW78078.1; -; Genomic_DNA.
DR EMBL; EU088794; ABW78079.1; -; Genomic_DNA.
DR EMBL; EU088795; ABW78080.1; -; Genomic_DNA.
DR EMBL; EU088796; ABW78081.1; -; Genomic_DNA.
DR EMBL; EU088797; ABW78082.1; -; Genomic_DNA.
DR EMBL; EU088798; ABW78083.1; -; Genomic_DNA.
DR EMBL; EU088799; ABW78084.1; -; Genomic_DNA.
DR EMBL; EU088800; ABW78085.1; -; Genomic_DNA.
DR EMBL; EU088801; ABW78086.1; -; Genomic_DNA.
DR EMBL; EU088802; ABW78087.1; -; Genomic_DNA.
DR EMBL; EU088803; ABW78088.1; -; Genomic_DNA.
DR EMBL; EU088804; ABW78089.1; -; Genomic_DNA.
DR EMBL; EU088805; ABW78090.1; -; Genomic_DNA.
DR EMBL; EU088806; ABW78091.1; -; Genomic_DNA.
DR EMBL; EU088807; ABW78092.1; -; Genomic_DNA.
DR EMBL; EU088808; ABW78093.1; -; Genomic_DNA.
DR EMBL; EU088809; ABW78094.1; -; Genomic_DNA.
DR EMBL; EU088810; ABW78095.1; -; Genomic_DNA.
DR EMBL; EU088811; ABW78096.1; -; Genomic_DNA.
DR EMBL; EU088812; ABW78097.1; -; Genomic_DNA.
DR EMBL; EU088813; ABW78098.1; -; Genomic_DNA.
DR EMBL; EU088814; ABW78099.1; -; Genomic_DNA.
DR EMBL; EU088815; ABW78100.1; -; Genomic_DNA.
DR EMBL; EU088816; ABW78101.1; -; Genomic_DNA.
DR EMBL; EU088817; ABW78102.1; -; Genomic_DNA.
DR EMBL; EU088818; ABW78103.1; -; Genomic_DNA.
DR EMBL; EU088819; ABW78104.1; -; Genomic_DNA.
DR EMBL; EU088820; ABW78105.1; -; Genomic_DNA.
DR EMBL; EU088821; ABW78106.1; -; Genomic_DNA.
DR EMBL; EU088822; ABW78107.1; -; Genomic_DNA.
DR EMBL; EU088823; ABW78108.1; -; Genomic_DNA.
DR EMBL; EU088824; ABW78109.1; -; Genomic_DNA.
DR EMBL; EU088825; ABW78110.1; -; Genomic_DNA.
DR EMBL; EU088826; ABW78111.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF57515.2; -; Genomic_DNA.
DR EMBL; BT023380; AAY55796.1; -; mRNA.
DR EMBL; BT029395; ABK56981.1; ALT_INIT; mRNA.
DR RefSeq; NP_001188979.1; NM_001202050.1.
DR RefSeq; NP_611448.2; NM_137604.2.
DR AlphaFoldDB; Q9V8Y9; -.
DR SMR; Q9V8Y9; -.
DR BioGRID; 62927; 2.
DR STRING; 7227.FBpp0085637; -.
DR PaxDb; Q9V8Y9; -.
DR DNASU; 37271; -.
DR EnsemblMetazoa; FBtr0086335; FBpp0085637; FBgn0034475.
DR EnsemblMetazoa; FBtr0302932; FBpp0292058; FBgn0034475.
DR GeneID; 37271; -.
DR KEGG; dme:Dmel_CG13874; -.
DR CTD; 37271; -.
DR FlyBase; FBgn0034475; Obp56h.
DR VEuPathDB; VectorBase:FBgn0034475; -.
DR eggNOG; ENOG502T810; Eukaryota.
DR HOGENOM; CLU_107288_3_1_1; -.
DR InParanoid; Q9V8Y9; -.
DR OMA; KEHKAMP; -.
DR OrthoDB; 1371933at2759; -.
DR PhylomeDB; Q9V8Y9; -.
DR BioGRID-ORCS; 37271; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37271; -.
DR PRO; PR:Q9V8Y9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034475; Expressed in mouthpart and 13 other tissues.
DR ExpressionAtlas; Q9V8Y9; baseline and differential.
DR Genevisible; Q9V8Y9; DM.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0007617; P:mating behavior; IMP:FlyBase.
DR GO; GO:0071834; P:mating pheromone secretion; IMP:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEP:UniProtKB.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Secreted;
KW Sensory transduction; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..134
FT /note="General odorant-binding protein 56h"
FT /id="PRO_0000012571"
FT DISULFID 30..63
FT /evidence="ECO:0000250"
FT DISULFID 59..114
FT /evidence="ECO:0000250"
FT DISULFID 105..123
FT /evidence="ECO:0000250"
FT VARIANT 7
FT /note="C -> G (in strain: 357A, 774A and 786A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 13
FT /note="F -> L (in strain: 357A, 774A and 786A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 22
FT /note="D -> G (in strain: 868A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 39
FT /note="A -> D (in strain: 315A, 765A, 822A and 832A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 44
FT /note="F -> L (in strain: 318A, 319A, 399A and 732A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 54
FT /note="K -> T (in strain: 306A, 313A, 358A, 359A, 390A,
FT 773A, 813A and 868A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 72
FT /note="T -> I (in strain: 774A and 786A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 79
FT /note="Q -> H (in strain: 774A and 786A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 92
FT /note="K -> T (in strain: 313A, 737A, 820A and 907A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 115
FT /note="D -> H (in strain: 307A, 318A, 390A, 705A, 707A,
FT 732A, 736A, 797A and 868A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 126
FT /note="E -> D (in strain: 705A, 740A and 907A)"
FT /evidence="ECO:0000269|PubMed:17720903"
FT VARIANT 127..128
FT /note="HK -> Q (in strain: 740A)"
FT /evidence="ECO:0000269|PubMed:17720903"
SQ SEQUENCE 134 AA; 14978 MW; 8FB7B47FF3672877 CRC64;
MKFTLFCIAL AAFLSMGQCN PDFRQIMQQC METNQVTEAD LKEFMASGMQ SSAKENLKCY
TKCLMEKQGH LTNGQFNAQA MLDTLKNVPQ IKDKMDEISS GVNACKDIKG TNDCDTAFKV
TMCLKEHKAI PGHH
