OB57A_DROME
ID OB57A_DROME Reviewed; 169 AA.
AC Q8MKK0; Q4V3M7;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=General odorant-binding protein 57a;
DE Flags: Precursor;
GN Name=Obp57a {ECO:0000312|EMBL:AAM68410.1}; ORFNames=CG30141;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAM69286.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAM69286.1};
RX PubMed=12119098; DOI=10.1016/s0378-1119(02)00672-8;
RA Graham L.A., Davies P.L.;
RT "The odorant-binding proteins of Drosophila melanogaster: annotation and
RT characterization of a divergent gene family.";
RL Gene 292:43-55(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAM68410.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM68410.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12213773; DOI=10.1101/gr.239402;
RA Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.;
RT "Genome-wide analysis of the odorant-binding protein gene family in
RT Drosophila melanogaster.";
RL Genome Res. 12:1357-1369(2002).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
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DR EMBL; AF457148; AAM69286.1; -; mRNA.
DR EMBL; AE013599; AAM68410.1; -; Genomic_DNA.
DR EMBL; BT023329; AAY55745.1; -; mRNA.
DR RefSeq; NP_725966.1; NM_166395.3.
DR AlphaFoldDB; Q8MKK0; -.
DR BioGRID; 73206; 1.
DR STRING; 7227.FBpp0085606; -.
DR PaxDb; Q8MKK0; -.
DR DNASU; 246670; -.
DR EnsemblMetazoa; FBtr0086294; FBpp0085606; FBgn0043535.
DR GeneID; 246670; -.
DR KEGG; dme:Dmel_CG30141; -.
DR CTD; 246670; -.
DR FlyBase; FBgn0043535; Obp57a.
DR VEuPathDB; VectorBase:FBgn0043535; -.
DR GeneTree; ENSGT00540000073618; -.
DR HOGENOM; CLU_1588250_0_0_1; -.
DR OMA; CAFKSGH; -.
DR OrthoDB; 1444221at2759; -.
DR PhylomeDB; Q8MKK0; -.
DR BioGRID-ORCS; 246670; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 246670; -.
DR PRO; PR:Q8MKK0; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0043535; Expressed in spermathecum and 13 other tissues.
DR Genevisible; Q8MKK0; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:1990834; P:response to odorant; NAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Sensory transduction;
KW Signal; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..169
FT /note="General odorant-binding protein 57a"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012572"
FT DISULFID 39..77
FT /evidence="ECO:0000250"
FT DISULFID 73..120
FT /evidence="ECO:0000250"
FT DISULFID 111..129
FT /evidence="ECO:0000250"
SQ SEQUENCE 169 AA; 19462 MW; 9F9DBC2FE1C6DA48 CRC64;
MFNTRLAIFL LLIVVSLSQA KESQPFDFFE GTYDDFIDCL RINNITIEEY EKFDDTDNLD
NVLKENVELK HKCNIKCQLE REPTKWLNAR GEVDLKSMKA TSETAVSISK CMEKAPQETC
AYVYKLVICA FKSGHSVIKF DSYEQIQEET AGLIAEQQAD LFDYDTIDL
