OB57B_DROME
ID OB57B_DROME Reviewed; 141 AA.
AC Q8MKJ4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=General odorant-binding protein 57b;
DE Flags: Precursor;
GN Name=Obp57b {ECO:0000312|EMBL:AAM68409.1}; ORFNames=CG30142;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAM69285.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAM69285.1};
RX PubMed=12119098; DOI=10.1016/s0378-1119(02)00672-8;
RA Graham L.A., Davies P.L.;
RT "The odorant-binding proteins of Drosophila melanogaster: annotation and
RT characterization of a divergent gene family.";
RL Gene 292:43-55(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAM68409.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM68409.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12213773; DOI=10.1101/gr.239402;
RA Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.;
RT "Genome-wide analysis of the odorant-binding protein gene family in
RT Drosophila melanogaster.";
RL Genome Res. 12:1357-1369(2002).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
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DR EMBL; AF457147; AAM69285.1; -; mRNA.
DR EMBL; AE013599; AAM68409.1; -; Genomic_DNA.
DR RefSeq; NP_001286632.1; NM_001299703.1.
DR RefSeq; NP_725965.1; NM_166394.3.
DR AlphaFoldDB; Q8MKJ4; -.
DR SMR; Q8MKJ4; -.
DR STRING; 7227.FBpp0085605; -.
DR PaxDb; Q8MKJ4; -.
DR EnsemblMetazoa; FBtr0086293; FBpp0085605; FBgn0043534.
DR EnsemblMetazoa; FBtr0342691; FBpp0309582; FBgn0043534.
DR GeneID; 246669; -.
DR KEGG; dme:Dmel_CG30142; -.
DR CTD; 246669; -.
DR FlyBase; FBgn0043534; Obp57b.
DR VEuPathDB; VectorBase:FBgn0043534; -.
DR GeneTree; ENSGT00540000073618; -.
DR HOGENOM; CLU_1588250_0_0_1; -.
DR InParanoid; Q8MKJ4; -.
DR OMA; RYKCNIK; -.
DR OrthoDB; 1444221at2759; -.
DR PhylomeDB; Q8MKJ4; -.
DR BioGRID-ORCS; 246669; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 246669; -.
DR PRO; PR:Q8MKJ4; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0043534; Expressed in mouthpart and 12 other tissues.
DR ExpressionAtlas; Q8MKJ4; baseline and differential.
DR Genevisible; Q8MKJ4; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:1990834; P:response to odorant; NAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Sensory transduction;
KW Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..141
FT /note="General odorant-binding protein 57b"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012573"
FT DISULFID 39..77
FT /evidence="ECO:0000250"
FT DISULFID 73..120
FT /evidence="ECO:0000250"
FT DISULFID 111..129
FT /evidence="ECO:0000250"
SQ SEQUENCE 141 AA; 16663 MW; FBD7ACD2BE8F8EC5 CRC64;
MFIYRLVFIA PLILLLFSLA KARHPFDIFH WNWQDFQECL QVNNITIGEY EKYARHETLD
YLLNEKVDLR YKCNIKCQLE RDSTKWLNAQ GRMDLDLMNT TDKASKSITK CMEKAPEELC
AYSFRLVMCA FKAGHPVIDS E
