OB57C_DROME
ID OB57C_DROME Reviewed; 149 AA.
AC Q9V931; A8DYJ8; Q4V3N2;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=General odorant-binding protein 57c;
DE Flags: Precursor;
GN Name=Obp57c {ECO:0000312|EMBL:AAF57467.1}; ORFNames=CG13421;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAF57467.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF57467.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL68372.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL68372.1};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12119098; DOI=10.1016/s0378-1119(02)00672-8;
RA Graham L.A., Davies P.L.;
RT "The odorant-binding proteins of Drosophila melanogaster: annotation and
RT characterization of a divergent gene family.";
RL Gene 292:43-55(2002).
RN [6] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12213773; DOI=10.1101/gr.239402;
RA Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.;
RT "Genome-wide analysis of the odorant-binding protein gene family in
RT Drosophila melanogaster.";
RL Genome Res. 12:1357-1369(2002).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
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DR EMBL; AE013599; AAF57467.1; -; Genomic_DNA.
DR EMBL; AE013599; ABV53859.1; -; Genomic_DNA.
DR EMBL; AY075565; AAL68372.1; -; mRNA.
DR EMBL; BT023324; AAY55740.1; -; mRNA.
DR RefSeq; NP_611481.1; NM_137637.3.
DR AlphaFoldDB; Q9V931; -.
DR SMR; Q9V931; -.
DR IntAct; Q9V931; 15.
DR STRING; 7227.FBpp0085604; -.
DR PaxDb; Q9V931; -.
DR PRIDE; Q9V931; -.
DR DNASU; 37311; -.
DR EnsemblMetazoa; FBtr0086292; FBpp0085604; FBgn0034509.
DR GeneID; 37311; -.
DR KEGG; dme:Dmel_CG13421; -.
DR UCSC; CG13421-RB; d. melanogaster.
DR CTD; 37311; -.
DR FlyBase; FBgn0034509; Obp57c.
DR VEuPathDB; VectorBase:FBgn0034509; -.
DR eggNOG; ENOG502T9CN; Eukaryota.
DR HOGENOM; CLU_146927_0_0_1; -.
DR InParanoid; Q9V931; -.
DR OMA; KYKCFAH; -.
DR OrthoDB; 1475185at2759; -.
DR PhylomeDB; Q9V931; -.
DR BioGRID-ORCS; 37311; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37311; -.
DR PRO; PR:Q9V931; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034509; Expressed in mouthpart and 17 other tissues.
DR ExpressionAtlas; Q9V931; baseline and differential.
DR Genevisible; Q9V931; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:1990834; P:response to odorant; NAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Sensory transduction;
KW Signal; Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..149
FT /note="General odorant-binding protein 57c"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012574"
FT DISULFID 32..70
FT /evidence="ECO:0000250"
FT DISULFID 66..117
FT /evidence="ECO:0000250"
FT DISULFID 106..126
FT /evidence="ECO:0000250"
SQ SEQUENCE 149 AA; 17223 MW; 0957CE3FEA906BFE CRC64;
MLKLWLICIL TVSVVSIQSL SLLEETNYVS DCLASNNISQ AEFQELIDRN SSEEDDLENT
DRRYKCFIHC LAEKGNLLDT NGYLDVDKID QIEPVSDELR EILYDCKKIY DEEEDHCEYA
FKMVTCLTES FEQSDEVTEA GKNTNKLNE
