OB57D_DROME
ID OB57D_DROME Reviewed; 136 AA.
AC Q8MMF9; Q5KS14; Q5KS20; Q5KS26; Q5KS32; Q5KS34; Q8MVX5;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=General odorant-binding protein 57d;
DE Flags: Precursor;
GN Name=Obp57d {ECO:0000312|EMBL:AAM68388.1}; ORFNames=CG30150;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAM69287.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAM69287.1};
RX PubMed=12119098; DOI=10.1016/s0378-1119(02)00672-8;
RA Graham L.A., Davies P.L.;
RT "The odorant-binding proteins of Drosophila melanogaster: annotation and
RT characterization of a divergent gene family.";
RL Gene 292:43-55(2002).
RN [2] {ECO:0000312|EMBL:BAD83905.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Algeria {ECO:0000312|EMBL:BAD83910.1},
RC CA1 {ECO:0000312|EMBL:BAD83912.1}, KSA2 {ECO:0000312|EMBL:BAD83915.1},
RC KY02001G20 {ECO:0000312|EMBL:BAD83894.1},
RC KY02002G20 {ECO:0000312|EMBL:BAD83895.1},
RC KY02003G20 {ECO:0000312|EMBL:BAD83896.1},
RC KY02006G20 {ECO:0000312|EMBL:BAD83897.1},
RC KY02010G20 {ECO:0000312|EMBL:BAD83899.1},
RC KY02013G20 {ECO:0000312|EMBL:BAD83885.1},
RC KY02016G18 {ECO:0000312|EMBL:BAD83889.1},
RC KY02070G20 {ECO:0000312|EMBL:BAD83900.1},
RC KY02073G20 {ECO:0000312|EMBL:BAD83887.1},
RC KY02074G20 {ECO:0000312|EMBL:BAD83901.1},
RC KY02101G9 {ECO:0000312|EMBL:BAD83893.1},
RC KY02102G9 {ECO:0000312|EMBL:BAD83902.1},
RC KY02104G9 {ECO:0000312|EMBL:BAD83903.1},
RC KY02106G9 {ECO:0000312|EMBL:BAD83891.1},
RC KY02109G9 {ECO:0000312|EMBL:BAD83904.1},
RC MEL6G59 {ECO:0000312|EMBL:BAD83905.1}, MEL7 {ECO:0000312|EMBL:BAD83911.1},
RC MEL8 {ECO:0000312|EMBL:BAD83913.1}, and
RC TaiwanG23 {ECO:0000312|EMBL:BAD83907.1};
RA Takahashi A., Takano-Shimizu T.;
RT "A high frequency null mutant of an odrant-binding protein gene, Obp57e, in
RT Drosophila melanogaster.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM68388.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAM68388.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12213773; DOI=10.1101/gr.239402;
RA Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.;
RT "Genome-wide analysis of the odorant-binding protein gene family in
RT Drosophila melanogaster.";
RL Genome Res. 12:1357-1369(2002).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF457149; AAM69287.1; -; mRNA.
DR EMBL; AB189644; BAD83885.1; -; Genomic_DNA.
DR EMBL; AB189645; BAD83887.1; -; Genomic_DNA.
DR EMBL; AB189646; BAD83889.1; -; Genomic_DNA.
DR EMBL; AB189647; BAD83891.1; -; Genomic_DNA.
DR EMBL; AB189648; BAD83893.1; -; Genomic_DNA.
DR EMBL; AB189649; BAD83894.1; -; Genomic_DNA.
DR EMBL; AB189650; BAD83895.1; -; Genomic_DNA.
DR EMBL; AB189651; BAD83896.1; -; Genomic_DNA.
DR EMBL; AB189652; BAD83897.1; -; Genomic_DNA.
DR EMBL; AB189653; BAD83898.1; -; Genomic_DNA.
DR EMBL; AB189654; BAD83899.1; -; Genomic_DNA.
DR EMBL; AB189655; BAD83900.1; -; Genomic_DNA.
DR EMBL; AB189656; BAD83901.1; -; Genomic_DNA.
DR EMBL; AB189657; BAD83902.1; -; Genomic_DNA.
DR EMBL; AB189658; BAD83903.1; -; Genomic_DNA.
DR EMBL; AB189659; BAD83904.1; -; Genomic_DNA.
DR EMBL; AB189660; BAD83905.1; -; Genomic_DNA.
DR EMBL; AB189661; BAD83907.1; -; Genomic_DNA.
DR EMBL; AB189663; BAD83910.1; -; Genomic_DNA.
DR EMBL; AB189664; BAD83911.1; -; Genomic_DNA.
DR EMBL; AB189665; BAD83912.1; -; Genomic_DNA.
DR EMBL; AB189666; BAD83913.1; -; Genomic_DNA.
DR EMBL; AB189667; BAD83915.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68388.1; -; Genomic_DNA.
DR RefSeq; NP_725973.1; NM_166397.3.
DR AlphaFoldDB; Q8MMF9; -.
DR STRING; 7227.FBpp0289082; -.
DR PaxDb; Q8MMF9; -.
DR DNASU; 246671; -.
DR EnsemblMetazoa; FBtr0299804; FBpp0289082; FBgn0043536.
DR GeneID; 246671; -.
DR KEGG; dme:Dmel_CG30150; -.
DR CTD; 246671; -.
DR FlyBase; FBgn0043536; Obp57d.
DR VEuPathDB; VectorBase:FBgn0043536; -.
DR GeneTree; ENSGT00940000176564; -.
DR HOGENOM; CLU_154821_0_0_1; -.
DR InParanoid; Q8MMF9; -.
DR BioGRID-ORCS; 246671; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Obp57d; fly.
DR GenomeRNAi; 246671; -.
DR PRO; PR:Q8MMF9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0043536; Expressed in larva and 2 other tissues.
DR Genevisible; Q8MMF9; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:1990834; P:response to odorant; NAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Olfaction; Reference proteome; Sensory transduction;
KW Signal; Transport.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..136
FT /note="General odorant-binding protein 57d"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012575"
FT DISULFID 33..70
FT /evidence="ECO:0000250"
FT DISULFID 66..118
FT /evidence="ECO:0000250"
FT DISULFID 107..127
FT /evidence="ECO:0000250"
FT VARIANT 10
FT /note="V -> I (in strain: Canton-S, KY02013G20 and
FT KY02073G20)"
FT VARIANT 28
FT /note="D -> E (in strain: KY02106G9 and MEL6G59)"
FT VARIANT 58
FT /note="T -> I (in strain: Canton-S, KY02010G20, KY02013G20
FT and KY02073G20)"
FT VARIANT 87
FT /note="D -> E (in strain: KY02106G9)"
FT /evidence="ECO:0000269|Ref.2"
FT VARIANT 87
FT /note="D -> N (in strain: Canton-S, KY02010G20, KY02073G20
FT and KY02013G20)"
FT VARIANT 99
FT /note="A -> T (in strain: KY02106G9)"
FT /evidence="ECO:0000269|Ref.2"
FT CONFLICT 80
FT /note="T -> A (in Ref. 3; AAM68388)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 15747 MW; 3073A70754EE7A4F CRC64;
MPEKMSLRLV PHLACIIFIL EIQFRIADSN DPCPHNQGID EDIAESILGD WPANVDLTSV
KRSHKCYVTC ILQYYNIVTT SGEIFLDKYY DTGVIDELAV APKINRCRYE FRMETDYCSR
IFAIFNCLRQ EILTKS
