OB57E_DROME
ID OB57E_DROME Reviewed; 136 AA.
AC Q9V938; Q5KS09; Q5KS33;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 4.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=General odorant-binding protein 57e;
DE Flags: Precursor;
GN Name=Obp57e {ECO:0000312|EMBL:AAF57460.2}; ORFNames=CG30145;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:BAD83886.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-121 AND ASN-129.
RC STRAIN=KSA2 {ECO:0000312|EMBL:BAD83916.1},
RC KY02013G20 {ECO:0000312|EMBL:BAD83886.1},
RC KY02016G18 {ECO:0000312|EMBL:BAD83890.1},
RC KY02073G20 {ECO:0000312|EMBL:BAD83888.1},
RC KY02106G9 {ECO:0000312|EMBL:BAD83892.1},
RC MEL6G59 {ECO:0000312|EMBL:BAD83906.1}, and
RC MEL8 {ECO:0000312|EMBL:BAD83914.1};
RA Takahashi A., Takano-Shimizu T.;
RT "A high frequency null mutant of an odrant-binding protein gene, Obp57e, in
RT Drosophila melanogaster.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF57460.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF57460.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12119098; DOI=10.1016/s0378-1119(02)00672-8;
RA Graham L.A., Davies P.L.;
RT "The odorant-binding proteins of Drosophila melanogaster: annotation and
RT characterization of a divergent gene family.";
RL Gene 292:43-55(2002).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12213773; DOI=10.1101/gr.239402;
RA Hekmat-Scafe D.S., Scafe C.R., McKinney A.J., Tanouye M.A.;
RT "Genome-wide analysis of the odorant-binding protein gene family in
RT Drosophila melanogaster.";
RL Genome Res. 12:1357-1369(2002).
CC -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC dendrites and are thought to aid in the capture and transport of
CC hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB189644; BAD83886.1; -; Genomic_DNA.
DR EMBL; AB189645; BAD83888.1; -; Genomic_DNA.
DR EMBL; AB189646; BAD83890.1; -; Genomic_DNA.
DR EMBL; AB189647; BAD83892.1; -; Genomic_DNA.
DR EMBL; AB189660; BAD83906.1; -; Genomic_DNA.
DR EMBL; AB189666; BAD83914.1; -; Genomic_DNA.
DR EMBL; AB189667; BAD83916.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF57460.2; -; Genomic_DNA.
DR RefSeq; NP_611488.1; NM_137644.1.
DR AlphaFoldDB; Q9V938; -.
DR SMR; Q9V938; -.
DR STRING; 7227.FBpp0085577; -.
DR CAZy; CBM39; Carbohydrate-Binding Module Family 39.
DR PaxDb; Q9V938; -.
DR DNASU; 326110; -.
DR EnsemblMetazoa; FBtr0086265; FBpp0085577; FBgn0050145.
DR GeneID; 326110; -.
DR KEGG; dme:Dmel_CG30145; -.
DR CTD; 326110; -.
DR FlyBase; FBgn0050145; Obp57e.
DR VEuPathDB; VectorBase:FBgn0050145; -.
DR GeneTree; ENSGT00940000176564; -.
DR HOGENOM; CLU_154821_0_0_1; -.
DR InParanoid; Q9V938; -.
DR OMA; VQIDKYM; -.
DR OrthoDB; 1509188at2759; -.
DR PhylomeDB; Q9V938; -.
DR BioGRID-ORCS; 326110; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Obp57d; fly.
DR GenomeRNAi; 326110; -.
DR PRO; PR:Q9V938; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0050145; Expressed in arthropod fat body and 1 other tissue.
DR ExpressionAtlas; Q9V938; baseline and differential.
DR Genevisible; Q9V938; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:1990834; P:response to odorant; NAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Olfaction; Reference proteome; Sensory transduction;
KW Signal; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..136
FT /note="General odorant-binding protein 57e"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012576"
FT DISULFID 28..61
FT /evidence="ECO:0000250"
FT DISULFID 57..109
FT /evidence="ECO:0000250"
FT DISULFID 98..118
FT /evidence="ECO:0000250"
FT VARIANT 121
FT /note="D -> N (in strain: KY02106G9)"
FT /evidence="ECO:0000269|Ref.1"
FT VARIANT 129
FT /note="Y -> N (in strain: KY02106G9, MEL6G59 and KSA2)"
FT /evidence="ECO:0000269|Ref.1"
SQ SEQUENCE 136 AA; 15552 MW; 396B2EABD061509B CRC64;
MLDQLTLCLL LNFLCANVLA NTSVFNPCVS QNELSEYEAH QVMENWPVPP IDRAYKCFLT
CVLLDLGLID ERGNVQIDKY MKSGVVDWQW VAIELVTCRI EFSDERDLCE LSYGIFNCFK
DVKLAAEKYV SISNAK
