OB59A_DROME
ID OB59A_DROME Reviewed; 202 AA.
AC Q86BF9; Q29QE9;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Odorant-binding protein 59a {ECO:0000312|FlyBase:FBgn0034766};
DE Flags: Precursor;
GN Name=Obp59a {ECO:0000312|FlyBase:FBgn0034766};
GN Synonyms=Obp58a {ECO:0000312|FlyBase:FBgn0034766};
GN ORFNames=CG13517 {ECO:0000312|FlyBase:FBgn0034766};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ABC86503.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-202.
RC STRAIN=Berkeley {ECO:0000312|EMBL:ABC86503.1};
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=30230472; DOI=10.7554/elife.39249;
RA Sun J.S., Larter N.K., Chahda J.S., Rioux D., Gumaste A., Carlson J.R.;
RT "Humidity response depends on the small soluble protein Obp59a in
RT Drosophila.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Odorant-binding protein required for hygrotaxis behavior in
CC humidity-detecting sensilla. {ECO:0000269|PubMed:30230472}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30230472}.
CC -!- TISSUE SPECIFICITY: Expressed in non-neuronal cells in hygrosensitive
CC sensilla in the second chamber of the sacculus of the antenna third
CC segment (at protein level). {ECO:0000269|PubMed:30230472}.
CC -!- DISRUPTION PHENOTYPE: Viable with no morphological, mobility or
CC chemosensory response defects (PubMed:30230472). Results in defective
CC hygrotaxis behavior which might be related to increased desiccation
CC resistance and overall longer lifespan (PubMed:30230472).
CC {ECO:0000269|PubMed:30230472}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR EMBL; AE013599; AAO41344.1; -; Genomic_DNA.
DR EMBL; BT024441; ABC86503.1; -; mRNA.
DR RefSeq; NP_788429.1; NM_176249.3.
DR AlphaFoldDB; Q86BF9; -.
DR SMR; Q86BF9; -.
DR STRING; 7227.FBpp0071781; -.
DR PaxDb; Q86BF9; -.
DR EnsemblMetazoa; FBtr0071870; FBpp0071781; FBgn0034766.
DR GeneID; 37605; -.
DR KEGG; dme:Dmel_CG13517; -.
DR UCSC; CG13517-RB; d. melanogaster.
DR CTD; 37605; -.
DR FlyBase; FBgn0034766; Obp59a.
DR VEuPathDB; VectorBase:FBgn0034766; -.
DR eggNOG; ENOG502SBM2; Eukaryota.
DR HOGENOM; CLU_119225_0_0_1; -.
DR InParanoid; Q86BF9; -.
DR OMA; DRRKVSY; -.
DR OrthoDB; 1516246at2759; -.
DR PhylomeDB; Q86BF9; -.
DR BioGRID-ORCS; 37605; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37605; -.
DR PRO; PR:Q86BF9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034766; Expressed in sacculus (Drosophila) and 7 other tissues.
DR Genevisible; Q86BF9; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0090547; P:response to low humidity; IMP:FlyBase.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 1: Evidence at protein level;
KW Behavior; Reference proteome; Secreted; Signal; Sulfation.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..202
FT /note="Odorant-binding protein 59a"
FT /evidence="ECO:0000255"
FT /id="PRO_5004302281"
FT REGION 43..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 23361 MW; C082B4D68B607C3C CRC64;
MKQLIFLLIC LSCGTCSIYA LKCRSQEGLS EAELKRTVRN CMHRQDEDED RGRGGQGRQG
NGYEYGYGMD HDQEEQDRNP GNRGGYGNRR QRGLRQSDGR NHTSNDGGQC VAQCFFEEMN
MVDGNGMPDR RKVSYLLTKD LRDRELRNFF TDTVQQCFRY LESNGRGRHH KCSAARELVK
CMSEYAKAQC EDWEEHGNML FN
