OB83A_DROME
ID OB83A_DROME Reviewed; 154 AA.
AC P54193; Q059D8; Q9VNK2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=General odorant-binding protein 83a;
DE AltName: Full=Odorant-binding protein 83a;
DE AltName: Full=Odorant-binding protein OS-F;
DE AltName: Full=Pheromone-binding protein-related protein 3;
DE Short=PBPRP-3;
DE Flags: Precursor;
GN Name=Obp83a; Synonyms=OS-F, Pbprp3; ORFNames=CG11421;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Antenna;
RX PubMed=7545907; DOI=10.1016/0896-6273(94)90150-3;
RA Pikielny C.W., Hasan G., Rouyer F., Rosbash M.;
RT "Members of a family of Drosophila putative odorant-binding proteins are
RT expressed in different subsets of olfactory hairs.";
RL Neuron 12:35-49(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=CS-5; TISSUE=Antenna;
RX PubMed=8206941; DOI=10.1016/s0021-9258(17)34013-9;
RA McKenna M.P., Hekmat-Scafe D.S., Gaines P., Carlson J.R.;
RT "Putative Drosophila pheromone-binding proteins expressed in a subregion of
RT the olfactory system.";
RL J. Biol. Chem. 269:16340-16347(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S;
RX PubMed=9030621; DOI=10.1523/jneurosci.17-05-01616.1997;
RA Hekmat-Scafe D.S., Steinbrecht R.A., Carlson J.R.;
RT "Coexpression of two odorant-binding protein homologs in Drosophila:
RT implications for olfactory coding.";
RL J. Neurosci. 17:1616-1624(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M11, M13, M2, M20, M22, M23, M26, M36, M40, M47, M54, M55, M59, and
RC M66;
RX PubMed=14668382; DOI=10.1093/genetics/165.3.1279;
RA Sanchez-Gracia A., Aguade M., Rozas J.;
RT "Patterns of nucleotide polymorphism and divergence in the odorant-binding
RT protein genes OS-E and OS-F: analysis in the melanogaster species subgroup
RT of Drosophila.";
RL Genetics 165:1279-1288(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C.,
RA Celniker S.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted in the
CC lumen of olfactory hairs. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: In the ventrolateral region of the antenna,
CC expressed in two distinct types of olfactory hairs: in most sensilla
CC trichodea and in a subset of the small sensilla basiconica (at protein
CC level). {ECO:0000269|PubMed:7545907, ECO:0000269|PubMed:8206941,
CC ECO:0000269|PubMed:9030621}.
CC -!- DEVELOPMENTAL STAGE: Expressed in adult but not in larval olfactory
CC organs. {ECO:0000269|PubMed:8206941}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABJ16963.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U05982; AAC46476.1; -; mRNA.
DR EMBL; U02542; AAA21355.1; -; mRNA.
DR EMBL; U81503; AAB51684.1; -; Genomic_DNA.
DR EMBL; AJ574644; CAE00883.1; -; Genomic_DNA.
DR EMBL; AJ574762; CAE00418.1; -; Genomic_DNA.
DR EMBL; AJ574763; CAE00420.1; -; Genomic_DNA.
DR EMBL; AJ574764; CAE00422.1; -; Genomic_DNA.
DR EMBL; AJ574765; CAE00424.1; -; Genomic_DNA.
DR EMBL; AJ574766; CAE00426.1; -; Genomic_DNA.
DR EMBL; AJ574767; CAE00428.1; -; Genomic_DNA.
DR EMBL; AJ574768; CAE00430.1; -; Genomic_DNA.
DR EMBL; AJ574769; CAE00432.1; -; Genomic_DNA.
DR EMBL; AJ574770; CAE00434.1; -; Genomic_DNA.
DR EMBL; AJ574771; CAE00436.1; -; Genomic_DNA.
DR EMBL; AJ574772; CAE00438.1; -; Genomic_DNA.
DR EMBL; AJ574773; CAE00440.1; -; Genomic_DNA.
DR EMBL; AJ574774; CAE00442.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF51929.2; -; Genomic_DNA.
DR EMBL; BT029030; ABJ16963.1; ALT_INIT; mRNA.
DR RefSeq; NP_001287189.1; NM_001300260.1.
DR RefSeq; NP_001287190.1; NM_001300261.1.
DR RefSeq; NP_524241.1; NM_079517.3.
DR AlphaFoldDB; P54193; -.
DR SMR; P54193; -.
DR STRING; 7227.FBpp0078305; -.
DR PaxDb; P54193; -.
DR PRIDE; P54193; -.
DR DNASU; 40737; -.
DR EnsemblMetazoa; FBtr0078656; FBpp0078305; FBgn0011281.
DR EnsemblMetazoa; FBtr0345250; FBpp0311427; FBgn0011281.
DR GeneID; 40737; -.
DR KEGG; dme:Dmel_CG11421; -.
DR CTD; 40737; -.
DR FlyBase; FBgn0011281; Obp83a.
DR VEuPathDB; VectorBase:FBgn0011281; -.
DR eggNOG; ENOG502S7DV; Eukaryota.
DR GeneTree; ENSGT00520000056125; -.
DR HOGENOM; CLU_107288_1_0_1; -.
DR InParanoid; P54193; -.
DR OMA; YMYCLWE; -.
DR OrthoDB; 1145531at2759; -.
DR PhylomeDB; P54193; -.
DR BioGRID-ORCS; 40737; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40737; -.
DR PRO; PR:P54193; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011281; Expressed in head capsule and 13 other tissues.
DR ExpressionAtlas; P54193; baseline and differential.
DR Genevisible; P54193; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0005550; F:pheromone binding; ISS:FlyBase.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..154
FT /note="General odorant-binding protein 83a"
FT /id="PRO_0000012588"
FT DISULFID 55..86
FT /evidence="ECO:0000250"
FT DISULFID 82..133
FT /evidence="ECO:0000250"
FT DISULFID 124..142
FT /evidence="ECO:0000250"
SQ SEQUENCE 154 AA; 17326 MW; F46FFB077A069279 CRC64;
MALNGFGRRV SASVLLIALS LLSGALILPP AAAQRDENYP PPGILKMAKP FHDACVEKTG
VTEAAIKEFS DGEIHEDEKL KCYMNCFFHE IEVVDDNGDV HLEKLFATVP LSMRDKLMEM
SKGCVHPEGD TLCHKAWWFH QCWKKADPKH YFLP
