OB84A_DROME
ID OB84A_DROME Reviewed; 175 AA.
AC P54194; A8JQU8; B3DN19; Q9VI86;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=General odorant-binding protein 84a;
DE AltName: Full=Odorant-binding protein 84a;
DE AltName: Full=Pheromone-binding protein-related protein 4;
DE Short=PBPRP-4;
DE Flags: Precursor;
GN Name=Obp84a; Synonyms=Pbprp4; ORFNames=CG1176;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Antenna;
RX PubMed=7545907; DOI=10.1016/0896-6273(94)90150-3;
RA Pikielny C.W., Hasan G., Rouyer F., Rosbash M.;
RT "Members of a family of Drosophila putative odorant-binding proteins are
RT expressed in different subsets of olfactory hairs.";
RL Neuron 12:35-49(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted in the
CC lumen of olfactory hairs. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P54194-1; Sequence=Displayed;
CC Name=C;
CC IsoId=P54194-2; Sequence=VSP_038967;
CC -!- TISSUE SPECIFICITY: Present only in a small number of hairs scattered
CC over the surface of the funiculus. {ECO:0000269|PubMed:7545907}.
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DR EMBL; U05984; AAC46477.1; -; mRNA.
DR EMBL; AE014297; AAF54039.1; -; Genomic_DNA.
DR EMBL; AE014297; ABW08613.2; -; Genomic_DNA.
DR EMBL; BT032807; ACD81821.1; -; mRNA.
DR EMBL; BT032823; ACD81837.1; -; mRNA.
DR RefSeq; NP_001097700.2; NM_001104230.3. [P54194-2]
DR RefSeq; NP_476990.1; NM_057642.3. [P54194-1]
DR AlphaFoldDB; P54194; -.
DR SMR; P54194; -.
DR STRING; 7227.FBpp0289293; -.
DR PaxDb; P54194; -.
DR DNASU; 40874; -.
DR EnsemblMetazoa; FBtr0081597; FBpp0081115; FBgn0011282. [P54194-1]
DR EnsemblMetazoa; FBtr0300016; FBpp0289293; FBgn0011282. [P54194-2]
DR GeneID; 40874; -.
DR KEGG; dme:Dmel_CG1176; -.
DR CTD; 40874; -.
DR FlyBase; FBgn0011282; Obp84a.
DR VEuPathDB; VectorBase:FBgn0011282; -.
DR eggNOG; ENOG502SG48; Eukaryota.
DR HOGENOM; CLU_109094_0_0_1; -.
DR InParanoid; P54194; -.
DR OMA; HGCNASF; -.
DR PhylomeDB; P54194; -.
DR BioGRID-ORCS; 40874; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40874; -.
DR PRO; PR:P54194; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011282; Expressed in head capsule and 16 other tissues.
DR Genevisible; P54194; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0005550; F:pheromone binding; ISS:FlyBase.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..175
FT /note="General odorant-binding protein 84a"
FT /id="PRO_0000012589"
FT DISULFID 103..151
FT /evidence="ECO:0000250"
FT DISULFID 140..160
FT /evidence="ECO:0000250"
FT VAR_SEQ 2..5
FT /note="YSAL -> FHSLYLIGILSLIWVAAQDIVPDDPEVQMQMHAMFYTARVACAD
FT ENLIPY (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_038967"
SQ SEQUENCE 175 AA; 19513 MW; 76339DADEC76C7F5 CRC64;
MYSALVRACA VIAFLILSPN CARALQDHAK DNGDIFIINY DSFDGDVDDI STTTSAPREA
DYVDFDEVNR NCNASFITSM TNVLQFNNTG DLPDDKDKVT SMCYFHCFFE KSGLMTDYKL
NTDLVRKYVW PATGDSVEAC EAEGKDETNA CMRGYAIVKC VFTRALTDAR NKPTV
