OBA5_DROME
ID OBA5_DROME Reviewed; 210 AA.
AC P54185; Q9VPZ9;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Putative odorant-binding protein A5;
DE AltName: Full=Antennal protein 5;
DE Flags: Precursor;
GN Name=a5; ORFNames=CG5430;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S; TISSUE=Antenna;
RX PubMed=7545907; DOI=10.1016/0896-6273(94)90150-3;
RA Pikielny C.W., Hasan G., Rouyer F., Rosbash M.;
RT "Members of a family of Drosophila putative odorant-binding proteins are
RT expressed in different subsets of olfactory hairs.";
RL Neuron 12:35-49(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted in the
CC lumen of the sensilla. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Cells at the bases of a few scattered sensilla on
CC the posterior surface of the antenna.
CC -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U05243; AAC46472.1; -; mRNA.
DR EMBL; AE014134; AAF51385.1; -; Genomic_DNA.
DR RefSeq; NP_476998.1; NM_057650.3.
DR AlphaFoldDB; P54185; -.
DR SMR; P54185; -.
DR BioGRID; 59566; 2.
DR DIP; DIP-19357N; -.
DR IntAct; P54185; 1.
DR STRING; 7227.FBpp0077588; -.
DR PaxDb; P54185; -.
DR EnsemblMetazoa; FBtr0077922; FBpp0077588; FBgn0011294.
DR GeneID; 33317; -.
DR KEGG; dme:Dmel_CG5430; -.
DR CTD; 33317; -.
DR FlyBase; FBgn0011294; a5.
DR VEuPathDB; VectorBase:FBgn0011294; -.
DR eggNOG; KOG3346; Eukaryota.
DR GeneTree; ENSGT00940000170081; -.
DR HOGENOM; CLU_043994_5_1_1; -.
DR InParanoid; P54185; -.
DR OMA; PNRENPM; -.
DR OrthoDB; 1557122at2759; -.
DR PhylomeDB; P54185; -.
DR BioGRID-ORCS; 33317; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33317; -.
DR PRO; PR:P54185; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0011294; Expressed in head capsule and 6 other tissues.
DR Genevisible; P54185; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00866; PEBP_euk; 1.
DR Gene3D; 3.90.280.10; -; 1.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR035810; PEBP_euk.
DR InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR PANTHER; PTHR11362; PTHR11362; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; SSF49777; 1.
DR PROSITE; PS01220; PBP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..210
FT /note="Putative odorant-binding protein A5"
FT /id="PRO_0000023281"
FT CONFLICT 13
FT /note="F -> W (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="W -> R (in Ref. 1; AAC46472)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 24573 MW; 1DB9C0AFAD286719 CRC64;
MKLPALHLLF LGFICLARSQ DNDENVRRIM KEMEVIPEIL DEPPRELLRI KYDNTIDIEE
GKTYTPTELK FQPRLDWNAD PESFYTVLMI CPDAPNRENP MYRSWLHWLV VNVPGLDIMK
GQPISEYFGP LPPKDSGIQR YLILVYQQSD KLDFDEKKME LSNADGHSNF DVMKFTQKYE
MGSPVAGNIF QSRWDEYVPE LMKTLYGVSE
