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OBE4_ARATH
ID   OBE4_ARATH              Reviewed;        1162 AA.
AC   Q84TI3; Q9LY65;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein OBERON 4 {ECO:0000305};
DE   AltName: Full=Protein TITANIA 1 {ECO:0000303|PubMed:22378640};
GN   Name=OBE4 {ECO:0000305};
GN   OrderedLocusNames=At3g63500 {ECO:0000312|Araport:AT3G63500};
GN   ORFNames=MAA21.130 {ECO:0000312|EMBL:CAB87803.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INTERACTION WITH OBE1 AND OBE2.
RX   PubMed=19392692; DOI=10.1111/j.1365-313x.2009.03874.x;
RA   Thomas C.L., Schmidt D., Bayer E.M., Dreos R., Maule A.J.;
RT   "Arabidopsis plant homeodomain finger proteins operate downstream of auxin
RT   accumulation in specifying the vasculature and primary root meristem.";
RL   Plant J. 59:426-436(2009).
RN   [6]
RP   FUNCTION, INTERACTION WITH OBE1; OBE2 AND OBE3, DEVELOPMENTAL STAGE, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=22378640; DOI=10.1242/dev.074492;
RA   Saiga S., Moeller B., Watanabe-Taneda A., Abe M., Weijers D., Komeda Y.;
RT   "Control of embryonic meristem initiation in Arabidopsis by PHD-finger
RT   protein complexes.";
RL   Development 139:1391-1398(2012).
RN   [7]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27196372; DOI=10.1371/journal.pone.0155657;
RA   Lin T.F., Saiga S., Abe M., Laux T.;
RT   "OBE3 and WUS interaction in shoot meristem stem cell regulation.";
RL   PLoS ONE 11:E0155657-E0155657(2016).
CC   -!- FUNCTION: Probable transcription factor that functions redundantly with
CC       OBE3 in specification of the hypophysis and establishment of the
CC       embryonic root (PubMed:22378640). Involved in the activation of
CC       ARF5/MP-dependent gene expression during embryonic root meristem
CC       initiation (PubMed:22378640). Involved in shoot meristem homeostasis
CC       (PubMed:27196372). {ECO:0000269|PubMed:22378640,
CC       ECO:0000269|PubMed:27196372}.
CC   -!- SUBUNIT: Self-interacts (PubMed:22378640). Interacts with OBE1 and OBE2
CC       (PubMed:19392692, PubMed:22378640). Interacts with OBE3
CC       (PubMed:22378640). {ECO:0000269|PubMed:19392692,
CC       ECO:0000269|PubMed:22378640}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9S736}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q84TI3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q84TI3-2; Sequence=VSP_041312, VSP_041313;
CC   -!- DEVELOPMENTAL STAGE: Expressed in the two-cell stage embryo
CC       (PubMed:22378640). At early globular embryo stage, expressed both in
CC       the basal region of embryo proper and suspensor cells
CC       (PubMed:22378640). At heart and torpedo embryo stages expressed in the
CC       basal region apical regions of the embryo proper (PubMed:22378640).
CC       {ECO:0000269|PubMed:22378640}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions, but the double mutants tta1 and tta2 exhibit a rootless
CC       phenotype and seedling lethality (PubMed:22378640). No visible
CC       phenotype under normal growth conditions, but the double mutants obe3-2
CC       and obe4-2 exhibit broad growth defects and developmental arrest of
CC       seedlings (PubMed:27196372). {ECO:0000269|PubMed:22378640,
CC       ECO:0000269|PubMed:27196372}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB87803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL163818; CAB87803.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE80495.1; -; Genomic_DNA.
DR   EMBL; CP002686; ANM64027.1; -; Genomic_DNA.
DR   EMBL; BT005768; AAO64172.1; -; mRNA.
DR   EMBL; AK228553; BAF00474.1; -; mRNA.
DR   PIR; T49191; T49191.
DR   RefSeq; NP_001326078.1; NM_001340219.1. [Q84TI3-1]
DR   RefSeq; NP_191909.1; NM_116215.4. [Q84TI3-1]
DR   AlphaFoldDB; Q84TI3; -.
DR   SMR; Q84TI3; -.
DR   BioGRID; 10839; 6.
DR   STRING; 3702.AT3G63500.2; -.
DR   iPTMnet; Q84TI3; -.
DR   PaxDb; Q84TI3; -.
DR   PRIDE; Q84TI3; -.
DR   ProteomicsDB; 250854; -. [Q84TI3-1]
DR   EnsemblPlants; AT3G63500.2; AT3G63500.2; AT3G63500. [Q84TI3-1]
DR   EnsemblPlants; AT3G63500.3; AT3G63500.3; AT3G63500. [Q84TI3-1]
DR   GeneID; 825525; -.
DR   Gramene; AT3G63500.2; AT3G63500.2; AT3G63500. [Q84TI3-1]
DR   Gramene; AT3G63500.3; AT3G63500.3; AT3G63500. [Q84TI3-1]
DR   KEGG; ath:AT3G63500; -.
DR   Araport; AT3G63500; -.
DR   TAIR; locus:2087403; AT3G63500.
DR   eggNOG; ENOG502QPTA; Eukaryota.
DR   HOGENOM; CLU_006737_1_0_1; -.
DR   InParanoid; Q84TI3; -.
DR   OrthoDB; 183360at2759; -.
DR   PRO; PR:Q84TI3; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q84TI3; baseline and differential.
DR   Genevisible; Q84TI3; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001708; P:cell fate specification; IGI:TAIR.
DR   GO; GO:0090421; P:embryonic meristem initiation; IGI:TAIR.
DR   GO; GO:0009880; P:embryonic pattern specification; IGI:TAIR.
DR   InterPro; IPR004082; OBERON.
DR   InterPro; IPR032535; Oberon_cc.
DR   InterPro; IPR032881; Oberon_PHD.
DR   PANTHER; PTHR21736; PTHR21736; 1.
DR   Pfam; PF16312; Oberon_cc; 1.
DR   Pfam; PF07227; PHD_Oberon; 1.
DR   PRINTS; PR01544; ARATH130DUF.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1162
FT                   /note="Protein OBERON 4"
FT                   /id="PRO_0000399749"
FT   ZN_FING         835..899
FT                   /note="PHD-type"
FT   REGION          1..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1065..1161
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..460
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..187
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172, ECO:0000303|Ref.4"
FT                   /id="VSP_041312"
FT   VAR_SEQ         188..255
FT                   /note="KSEEEVQGKSSTTSSEMEEGELEPEPQPETASGLAHQTKHDCKLPSCSADDH
FT                   KNARIDRSFQEIGKSA -> MIRMLTENLPTRTVRPLPPTGASSRATTVTAGKMLPASP
FT                   GLFPVGDPIVTWIIIGQMPGTIDLRAPVS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172, ECO:0000303|Ref.4"
FT                   /id="VSP_041313"
SQ   SEQUENCE   1162 AA;  130732 MW;  5B65878EC17FCC7D CRC64;
     MKRLRSSDDL DFCNDKNVDG EPPNSDRPAS SSHRGFFSGN NRDRGEDAAG FSRAFSRRRS
     NRDLDNHRPD ARYHRSESAC FSRRAFPKGF RSERERPNRD ASVSSWRRFG GPGNDFGVDD
     RDRRLRDAER DRSLKSPSWS RDSPNELSKF KPLDSRNSRS RSKSLASPTW SKDSGSEQSK
     SVGNVVKKSE EEVQGKSSTT SSEMEEGELE PEPQPETASG LAHQTKHDCK LPSCSADDHK
     NARIDRSFQE IGKSAQLDAN TESNRELSHV GGNREMETTD SMTDKKSVED AENVPEHATE
     SMHVSQNNVN DTSTALAIEH DHRDGTITAS ANKITDTVDE KGDKDEDYKE NLHGVKLEET
     LYPDVPERLE ELKEVKGNDG DANKAEVEGP ECVEENALAN RTPAEYISSV SDSSVHKCKD
     KGKNSDVPLT HLVGNALFSE SKTEDLHDKD KDEKDDNFGG PSIRGFELFS SSPVRRAKKT
     EQSGVNKHKD EKLLLEPLDL SLSLPDVLLP IGGQDTNQLG SPVRSGSVRS LTDTFCTNSD
     GFTMSMSFSG SRSFNHNPSC SLSHNIGDNE QSVHSRPIFQ GIDWQALSHN DSKYNENTVY
     QRLMENGNGS VQPRAMKGNL ISGQADEEHL RLPDGSSKAA NILEKQLSFQ KSVDVRSACP
     RTGSLENGSK FTVEKKTAKD FYSGSNSWIT GLEAGGHDFV ETVIRYILSD SMPVMTKRFH
     EMPTRNITSL KENIRQMMLN MDKNVQLGAF QDALQNRTDI TLELLTKSHR AQLEILVALK
     SGRSDFLLLD NSISSSHLAE IFMNMRCKNL SCRVLLPVDE CDCRVCSRKD GFCSACMCLV
     CSNFDMASNT CSWVGCDVCL HWCHTDCGIK ESYIRNGINA SGAPGMTEMQ FHCVACNHPS
     EMFGFVKEVF LNFAREWKFE RFCKELEYVN KIFSSSKDSR GKQLRQAADA MLASLKSKLI
     GLPEACNRIL GFISDCDSST PAETSAPFIY EQPKPRHERG SPSQDTAWLR SVCSDNPHNQ
     LKRSASVADA FHRERQVEIC AVEMELERGS PKEPRFEELE SIVRMKQAEA EMFQGRADDA
     RREAEGLKRI AIAKKEKIEE EYNRRMGKLS MEDAQERRRR RYEELEAMQR GQREFYEMKM
     RMEEEMRGLL TKMEMTKQSL AL
 
 
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