OBF1_BOVIN
ID OBF1_BOVIN Reviewed; 256 AA.
AC Q2KJA4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=POU domain class 2-associating factor 1;
DE AltName: Full=B-cell-specific coactivator OBF-1;
DE AltName: Full=OCT-binding factor 1;
GN Name=POU2AF1; Synonyms=OBF1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional coactivator that specifically associates with
CC either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated
CC promoter activity and to a lesser extent, that of POU2F2/OCT2. It has
CC no intrinsic DNA-binding activity. It recognizes the POU domains of
CC POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-
CC cells to antigens and required for the formation of germinal centers.
CC Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator.
CC {ECO:0000250|UniProtKB:Q64693}.
CC -!- SUBUNIT: Interacts with POU2F1/OCT1 and POU2F2/OCT2; the interaction
CC increases POU2F1 and POU2F2 transactivation activity.
CC {ECO:0000250|UniProtKB:Q16633}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64693}.
CC -!- PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its
CC subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q16633}.
CC -!- SIMILARITY: Belongs to the POU2AF1 family. {ECO:0000305}.
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DR EMBL; BC105441; AAI05442.1; -; mRNA.
DR RefSeq; NP_001069383.1; NM_001075915.1.
DR AlphaFoldDB; Q2KJA4; -.
DR SMR; Q2KJA4; -.
DR STRING; 9913.ENSBTAP00000008246; -.
DR PaxDb; Q2KJA4; -.
DR Ensembl; ENSBTAT00000008246; ENSBTAP00000008246; ENSBTAG00000006282.
DR GeneID; 528475; -.
DR KEGG; bta:528475; -.
DR CTD; 5450; -.
DR VEuPathDB; HostDB:ENSBTAG00000006282; -.
DR VGNC; VGNC:33173; POU2AF1.
DR eggNOG; ENOG502R5JD; Eukaryota.
DR GeneTree; ENSGT00390000017499; -.
DR HOGENOM; CLU_095920_0_0_1; -.
DR InParanoid; Q2KJA4; -.
DR OMA; GQPCIDM; -.
DR OrthoDB; 1172888at2759; -.
DR TreeFam; TF332565; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000006282; Expressed in nasopharynx and 72 other tissues.
DR ExpressionAtlas; Q2KJA4; baseline and differential.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR GO; GO:0002314; P:germinal center B cell differentiation; ISS:UniProtKB.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR015389; PD-C2-AF1.
DR Pfam; PF09310; PD-C2-AF1; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..256
FT /note="POU domain class 2-associating factor 1"
FT /id="PRO_0000285835"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 27436 MW; DC53505BB863465F CRC64;
MLWQKPTAPE QAPAPPRPYQ GVRVKEPVKE LLRRKRGHAS SGASVTPTAV VLPHQPLATY
TTVGPSCLDM EVSASTVTEE GALCAGWLSQ PAPAALQPLA PWTPYTEYVS HEAVSCPYSA
DMYVQPVCPS YTVVGPSSVL TYASQPLITN VTTRSAAAPT VGPPLEGPEH QAPLTYFPWP
QPLSTLPTST LQYQPPAPAL PGPQFVQLPI SIPEPVLPDA EDPRRAIGSL TIDKLLLEEE
DSDTYALNHT LSVEGF
