OBGM_ARATH
ID OBGM_ARATH Reviewed; 493 AA.
AC F4HSD4; Q9LNY4; Q9LQN5;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Probable GTP-binding protein OBGM, mitochondrial;
DE Flags: Precursor;
GN Name=ATOBGM; OrderedLocusNames=At1g07615; ORFNames=F22G5.1, F24B9.32;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- FUNCTION: May bind GTP and have GTPase activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01047}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF75096.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g07620 has been split into 2 genes: At1g07615 and At1g07620.; Evidence={ECO:0000305};
CC Sequence=AAF79543.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007583; AAF75096.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC022464; AAF79543.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28149.1; -; Genomic_DNA.
DR EMBL; BX816302; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; F86210; F86210.
DR RefSeq; NP_001077476.1; NM_001084007.2.
DR AlphaFoldDB; F4HSD4; -.
DR SMR; F4HSD4; -.
DR STRING; 3702.AT1G07615.1; -.
DR PaxDb; F4HSD4; -.
DR PRIDE; F4HSD4; -.
DR ProteomicsDB; 250855; -.
DR EnsemblPlants; AT1G07615.1; AT1G07615.1; AT1G07615.
DR GeneID; 5007670; -.
DR Gramene; AT1G07615.1; AT1G07615.1; AT1G07615.
DR KEGG; ath:AT1G07615; -.
DR Araport; AT1G07615; -.
DR TAIR; locus:4010713419; AT1G07615.
DR eggNOG; KOG1489; Eukaryota.
DR HOGENOM; CLU_011747_5_2_1; -.
DR InParanoid; F4HSD4; -.
DR OMA; PRVGHWE; -.
DR OrthoDB; 1150635at2759; -.
DR PRO; PR:F4HSD4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HSD4; baseline and differential.
DR Genevisible; F4HSD4; AT.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR CDD; cd01898; Obg; 1.
DR Gene3D; 2.70.210.12; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR InterPro; IPR006169; GTP1_OBG_dom.
DR InterPro; IPR036726; GTP1_OBG_dom_sf.
DR InterPro; IPR045086; OBG_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11702; PTHR11702; 1.
DR Pfam; PF01018; GTP1_OBG; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF002401; GTP_bd_Obg/CgtA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF82051; SSF82051; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS51883; OBG; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Mitochondrion; Nucleotide-binding; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 29..493
FT /note="Probable GTP-binding protein OBGM, mitochondrial"
FT /id="PRO_0000424831"
FT DOMAIN 48..303
FT /note="Obg"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01231"
FT DOMAIN 304..476
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT REGION 65..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 310..317
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 356..360
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT CONFLICT 219
FT /note="D -> Y (in Ref. 3; BX816302)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="S -> R (in Ref. 3; BX816302)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="T -> K (in Ref. 3; BX816302)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 493 AA; 54300 MW; F4AC8FDA155D901D CRC64;
MWLIRAIVPV RYLGSYKRPQ KPPWMRNPVV FYSDFSEKKG KVAPLQETRM RDRFTLYARG
GEGGSGCSSV RRSRADRYGK PDGGNGGRGG DVILECTHAV WDFSGLQPHI KGGKAGHGTS
KNRIGNRGED KVLLVPIGTV IHLQEGEIPS QVENESPKDL DPWDLPGSLV EDPASEENSD
VHQETMSESD QDDTEQESLT RQLGMPKEAD FEDDDEEIDQ IRYNVAELTQ QGQRVIIARG
GEGGLGNVSA TRYVRGSKFA KSTIRQTNLR SMEDDAEEDD ERSSIKAGLL GSEAVLILEL
KSIADVGLVG MPNAGKSTLL GALSRAKPRV GHYAFTTLRP NLGNVNYDDF SMTVADIPGL
IKGAHQNRGL GHNFLRHIER TKVLAYVVDL ASGLDGCEGL TPWQQLRDLV MELEFHEEGL
SDRSSLIVAN KIDEEGAEER LKELKRRVKG VKIFPVCAVL EEGVAELKDG LKMLVDGNGE
PSERLKLENI CVD
