ARRD3_RAT
ID ARRD3_RAT Reviewed; 414 AA.
AC Q6TXF1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Arrestin domain-containing protein 3;
DE AltName: Full=Liver regeneration-related protein LRRG00048;
GN Name=Arrdc3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J.,
RA Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B.,
RA Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein that plays a role in regulating cell-surface
CC expression of adrenergic receptors and probably also other G protein-
CC coupled receptors. Plays a role in NEDD4-mediated ubiquitination and
CC endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May
CC recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein
CC that does not play a major role in recruiting NEDD4 to ADRB2, but
CC rather plays a role in a targeting ADRB2 to endosomes.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SUBUNIT: Interacts (via PPxY motifs) with NEDD4 (via WW domains).
CC Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via
CC PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B67}. Cell
CC membrane {ECO:0000250|UniProtKB:Q96B67}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q96B67}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q96B67}. Lysosome
CC {ECO:0000250|UniProtKB:Q96B67}. Endosome
CC {ECO:0000250|UniProtKB:Q96B67}. Early endosome
CC {ECO:0000250|UniProtKB:Q96B67}. Note=Associated with plasma membrane,
CC as well as with endosomes and lysosomes during endocytosis.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; AY383703; AAQ96261.1; -; mRNA.
DR RefSeq; NP_001007798.1; NM_001007797.1.
DR AlphaFoldDB; Q6TXF1; -.
DR SMR; Q6TXF1; -.
DR STRING; 10116.ENSRNOP00000067658; -.
DR PhosphoSitePlus; Q6TXF1; -.
DR PaxDb; Q6TXF1; -.
DR Ensembl; ENSRNOT00000106948; ENSRNOP00000078331; ENSRNOG00000045649.
DR GeneID; 309945; -.
DR KEGG; rno:309945; -.
DR CTD; 57561; -.
DR RGD; 1359478; Arrdc3.
DR eggNOG; KOG3780; Eukaryota.
DR GeneTree; ENSGT00940000155411; -.
DR HOGENOM; CLU_039221_1_1_1; -.
DR InParanoid; Q6TXF1; -.
DR OMA; WFLPVKL; -.
DR OrthoDB; 817924at2759; -.
DR PhylomeDB; Q6TXF1; -.
DR PRO; PR:Q6TXF1; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000045649; Expressed in lung and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0031699; F:beta-3 adrenergic receptor binding; ISO:RGD.
DR GO; GO:0060613; P:fat pad development; ISO:RGD.
DR GO; GO:0031649; P:heat generation; IEA:Ensembl.
DR GO; GO:0071878; P:negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; ISO:RGD.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0031651; P:negative regulation of heat generation; ISO:RGD.
DR GO; GO:0090327; P:negative regulation of locomotion involved in locomotory behavior; ISO:RGD.
DR GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; ISO:RGD.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; ISO:RGD.
DR GO; GO:0001659; P:temperature homeostasis; ISO:RGD.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; SSF81296; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Endosome; Lysosome; Membrane; Reference proteome;
KW Repeat.
FT CHAIN 1..414
FT /note="Arrestin domain-containing protein 3"
FT /id="PRO_0000244352"
FT REGION 393..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 346..349
FT /note="PPxY motif 1"
FT /evidence="ECO:0000305"
FT MOTIF 391..394
FT /note="PPxY motif 2"
FT /evidence="ECO:0000305"
FT COMPBIAS 398..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46301 MW; 8294F213ADA21590 CRC64;
MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT
ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNCEE GFSTIHSGRH EYAFSFELPQ
TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT
LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM
KEVKQLVANL RGESLSSGKT ETWDGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
LLLSLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLGLSLP ERPEAPPSYA EVVTEEQRRN
NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSSEDRPS CPSR
