ID   ARRD5_HUMAN             Reviewed;         342 AA.
AC   A6NEK1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Arrestin domain-containing protein 5;
GN   Name=ARRDC5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW69191.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC027319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471139; EAW69191.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_001073992.1; NM_001080523.1.
DR   AlphaFoldDB; A6NEK1; -.
DR   SMR; A6NEK1; -.
DR   BioGRID; 570456; 3.
DR   IntAct; A6NEK1; 2.
DR   MINT; A6NEK1; -.
DR   STRING; 9606.ENSP00000371200; -.
DR   iPTMnet; A6NEK1; -.
DR   PhosphoSitePlus; A6NEK1; -.
DR   BioMuta; ARRDC5; -.
DR   MassIVE; A6NEK1; -.
DR   PaxDb; A6NEK1; -.
DR   PeptideAtlas; A6NEK1; -.
DR   PRIDE; A6NEK1; -.
DR   ProteomicsDB; 987; -.
DR   Antibodypedia; 64955; 57 antibodies from 13 providers.
DR   DNASU; 645432; -.
DR   Ensembl; ENST00000381781.2; ENSP00000371200.2; ENSG00000205784.4.
DR   GeneID; 645432; -.
DR   KEGG; hsa:645432; -.
DR   UCSC; uc002mbm.3; human.
DR   CTD; 645432; -.
DR   DisGeNET; 645432; -.
DR   GeneCards; ARRDC5; -.
DR   HGNC; HGNC:31407; ARRDC5.
DR   HPA; ENSG00000205784; Tissue enriched (testis).
DR   neXtProt; NX_A6NEK1; -.
DR   OpenTargets; ENSG00000205784; -.
DR   VEuPathDB; HostDB:ENSG00000205784; -.
DR   eggNOG; KOG3780; Eukaryota.
DR   GeneTree; ENSGT00510000049183; -.
DR   HOGENOM; CLU_855171_0_0_1; -.
DR   InParanoid; A6NEK1; -.
DR   OrthoDB; 817924at2759; -.
DR   PhylomeDB; A6NEK1; -.
DR   TreeFam; TF313650; -.
DR   PathwayCommons; A6NEK1; -.
DR   SignaLink; A6NEK1; -.
DR   BioGRID-ORCS; 645432; 13 hits in 1060 CRISPR screens.
DR   ChiTaRS; ARRDC5; human.
DR   GenomeRNAi; 645432; -.
DR   Pharos; A6NEK1; Tdark.
DR   PRO; PR:A6NEK1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NEK1; protein.
DR   Bgee; ENSG00000205784; Expressed in left testis and 69 other tissues.
DR   ExpressionAtlas; A6NEK1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..342
FT                   /note="Arrestin domain-containing protein 5"
FT                   /id="PRO_0000309620"
SQ   SEQUENCE   342 AA;  38383 MW;  A009077E00D30F35 CRC64;
     MGDREECLST PQPPMSVVKS IELVLPEDRI YLAGSSIKGQ VILTLNSTLV DPIVKVELVG
     RGYVEWSEEA GASCDYSRNV ICNNKADYVH KTKTFPVEDN WLSAGSHTFD FHFNLPPRLP
     STFTSKFGHV FYFVQASCMG REHILAKKRM YLLVQGTSTF HKETPFQNPL FVEAEEKVSY
     NCCRQGTVCL QIQMERNTFT PGEKVVFTTE INNQTSKCIK TVVFALYAHI QYEGFTPSAE
     RRSRLDSSEL LRQEANTPVT RFNTTKVVST FNLPLLLSVS SSTQDGEIMH TRYELVTTVH
     LPWSLTSLKA KVPIIITSAS VDSAICQLSE DGVLPVNPDH QN