ID   A27_VAR67               Reviewed;         110 AA.
AC   P33816;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=14 kDa fusion protein;
GN   ORFNames=A27L, A30L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=6/58 / Isolate S/6;
RX   PubMed=15131152; DOI=10.1128/jcm.42.5.1940-1946.2004;
RA   Olson V.A., Laue T., Laker M.T., Babkin I.V., Drosten C., Shchelkunov S.N.,
RA   Niedrig M., Damon I.K., Meyer H.;
RT   "Real-time PCR system for detection of orthopoxviruses and simultaneous
RT   identification of smallpox virus.";
RL   J. Clin. Microbiol. 42:1940-1946(2004).
CC   -!- FUNCTION: Structural protein involved in the envelopment of mature
CC       virion (MV) to form the wrapped virion (WV). The wrapping consists of
CC       the addition of Golgi membranes to the mature virion. Participates in
CC       mature virion (MV) movement within the infected cell. May play an
CC       indirect role in MV-cell fusion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamers, covalently linked. Interacts with A17 and A26
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Located to the mature virion
CC       membrane via interaction with protein A17. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A27 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49075.1; -; Genomic_DNA.
DR   EMBL; X67115; CAA47501.1; -; Genomic_DNA.
DR   EMBL; AY223492; AAP48877.1; -; Genomic_DNA.
DR   PIR; D36851; D36851.
DR   RefSeq; NP_042178.1; NC_001611.1.
DR   SMR; P33816; -.
DR   GeneID; 1486508; -.
DR   KEGG; vg:1486508; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR   InterPro; IPR003436; Chordopox_Fusion/A27.
DR   Pfam; PF02346; Vac_Fusion; 1.
DR   PRINTS; PR01847; VIRALFUSION.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Virion.
FT   CHAIN           1..110
FT                   /note="14 kDa fusion protein"
FT                   /id="PRO_0000099214"
SQ   SEQUENCE   110 AA;  12485 MW;  6A0339E9CAE21655 CRC64;
     MDGTLFPGDD DLAIPATEFF STKAAKKPEA KREAIVKADG DNNEETLKQR LTNLEKKITN
     VTTKFEQIEK CCKRNDDVLF RLENHAETLR AAMISLAKKI DVQTGRRPYE