A28_AMEPV
ID A28_AMEPV Reviewed; 143 AA.
AC P29816; Q9EML8;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Envelope protein A28 homolog;
DE AltName: Full=Protein G4R;
GN OrderedLocusNames=AMV186; ORFNames=G4;
OS Amsacta moorei entomopoxvirus (AmEPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Entomopoxvirinae; Betaentomopoxvirus.
OX NCBI_TaxID=28321;
OH NCBI_TaxID=340055; Amsacta.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1942245; DOI=10.1128/jvi.65.12.6516-6527.1991;
RA Hall R.L., Moyer R.W.;
RT "Identification, cloning, and sequencing of a fragment of Amsacta moorei
RT entomopoxvirus DNA containing the spheroidin gene and three vaccinia virus-
RT related open reading frames.";
RL J. Virol. 65:6516-6527(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10936094; DOI=10.1006/viro.2000.0449;
RA Bawden A.L., Glassberg K.J., Diggans J., Shaw R., Farmerie W., Moyer R.W.;
RT "Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis
RT and comparison with other poxviruses.";
RL Virology 274:120-139(2000).
CC -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC mature virion (IMV) membrane. {ECO:0000250}.
CC -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC that operates on the cytoplasmic side of the MV membranes (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA42382.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAG02892.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; M77182; AAA42382.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF250284; AAG02892.1; ALT_INIT; Genomic_DNA.
DR PIR; D41561; WMVZG4.
DR RefSeq; NP_064968.2; NC_002520.1.
DR GeneID; 1494776; -.
DR KEGG; vg:1494776; -.
DR Proteomes; UP000000872; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR007664; Poxvirus_A28.
DR Pfam; PF04584; Pox_A28; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix; Viral envelope protein;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT CHAIN 1..143
FT /note="Envelope protein A28 homolog"
FT /id="PRO_0000099304"
FT TRANSMEM 1..21
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..143
FT /note="Virion surface"
FT /evidence="ECO:0000255"
SQ SEQUENCE 143 AA; 16602 MW; C75D52B38C81EE4D CRC64;
MNTVQILVVI LITTALSFLV FQLWYYAENY EYILRYNDTY SNLQFARSAN INFDDLTVFD
PNDNVFNVEE KWRCASTNNN IFYAVSTFGF LSTESTGINL TYTNSRDCII DLFSRIIKIV
YDPCTVETSN DCRLLRLLMA NTS