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A28_AMEPV
ID   A28_AMEPV               Reviewed;         143 AA.
AC   P29816; Q9EML8;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Envelope protein A28 homolog;
DE   AltName: Full=Protein G4R;
GN   OrderedLocusNames=AMV186; ORFNames=G4;
OS   Amsacta moorei entomopoxvirus (AmEPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Entomopoxvirinae; Betaentomopoxvirus.
OX   NCBI_TaxID=28321;
OH   NCBI_TaxID=340055; Amsacta.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1942245; DOI=10.1128/jvi.65.12.6516-6527.1991;
RA   Hall R.L., Moyer R.W.;
RT   "Identification, cloning, and sequencing of a fragment of Amsacta moorei
RT   entomopoxvirus DNA containing the spheroidin gene and three vaccinia virus-
RT   related open reading frames.";
RL   J. Virol. 65:6516-6527(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10936094; DOI=10.1006/viro.2000.0449;
RA   Bawden A.L., Glassberg K.J., Diggans J., Shaw R., Farmerie W., Moyer R.W.;
RT   "Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis
RT   and comparison with other poxviruses.";
RL   Virology 274:120-139(2000).
CC   -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC       for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the MV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA42382.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAG02892.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M77182; AAA42382.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF250284; AAG02892.1; ALT_INIT; Genomic_DNA.
DR   PIR; D41561; WMVZG4.
DR   RefSeq; NP_064968.2; NC_002520.1.
DR   GeneID; 1494776; -.
DR   KEGG; vg:1494776; -.
DR   Proteomes; UP000000872; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007664; Poxvirus_A28.
DR   Pfam; PF04584; Pox_A28; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..143
FT                   /note="Envelope protein A28 homolog"
FT                   /id="PRO_0000099304"
FT   TRANSMEM        1..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..143
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  16602 MW;  C75D52B38C81EE4D CRC64;
     MNTVQILVVI LITTALSFLV FQLWYYAENY EYILRYNDTY SNLQFARSAN INFDDLTVFD
     PNDNVFNVEE KWRCASTNNN IFYAVSTFGF LSTESTGINL TYTNSRDCII DLFSRIIKIV
     YDPCTVETSN DCRLLRLLMA NTS
 
 
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