ID   ARRS_LITCT              Reviewed;         396 AA.
AC   P51478;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=S-arrestin;
DE   AltName: Full=Retinal S-antigen;
DE            Short=S-AG;
DE   AltName: Full=Rod photoreceptor arrestin;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=8536686; DOI=10.1111/j.1432-1033.1995.437_b.x;
RA   Abdulaeva G., Hargrave P.A., Smith W.C.;
RT   "The sequence of arrestins from rod and cone photoreceptors in the frogs
RT   Rana catesbeiana and Rana pipiens. Localization of gene transcripts by
RT   reverse-transcription polymerase chain reaction on isolated
RT   photoreceptors.";
RL   Eur. J. Biochem. 234:437-442(1995).
CC   -!- FUNCTION: Arrestin is one of the major proteins of the ros (retinal rod
CC       outer segments); it binds to photoactivated-phosphorylated rhodopsin,
CC       thereby apparently preventing the transducin-mediated activation of
CC       phosphodiesterase.
CC   -!- MISCELLANEOUS: Arrestin binds calcium.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; U30267; AAC59748.1; -; mRNA.
DR   EMBL; X92399; CAA63136.1; -; mRNA.
DR   PIR; S68174; S68174.
DR   AlphaFoldDB; P51478; -.
DR   SMR; P51478; -.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.640; -; 1.
DR   Gene3D; 2.60.40.840; -; 1.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR017864; Arrestin_CS.
DR   InterPro; IPR014753; Arrestin_N.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11792; PTHR11792; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Sensory transduction; Vision.
FT   CHAIN           1..396
FT                   /note="S-arrestin"
FT                   /id="PRO_0000205190"
SQ   SEQUENCE   396 AA;  44790 MW;  28EEE08EBBCCEF7A CRC64;
     MSGDKKSRSV IYKKTSRDKA VSVYLGKRDY VDHIESVDPV DGVVFVDPDL LKGKKVYVTL
     TCAFRYGNED IDVIGLTFRK DLFFARTQVY PPVEDVKCLT KVQERLMKKL GNNAYPFVMA
     FPDYLPCSVS LQPALSDVNK ACGVDFEVKA FSASNLEDRY HKKNSVRLLI RKIQYAPDQP
     GPTPRAETSW QFFMSDKPLH LTASLAKEVF YHGETITVAV TVTNSSEKTV KKISTSVEQT
     ANVVLYSSDF YTKTVAFDES DEKVSPKSTY KHTFTLLPLL AYNREKREIA LDGKLKHEDT
     NLASSTLLKE GIDRTVMGIL VDYKIKVTLT VSGLLGDMTS SEVSTELPFI LMHPKPDSGA
     KESEQEEDFV FEDFARDQLK DELQPEEKEE EEEDEK