ID   ARRS_LITPI              Reviewed;         396 AA.
AC   P51479;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=S-arrestin;
DE   AltName: Full=Retinal S-antigen;
DE            Short=S-AG;
DE   AltName: Full=Rod photoreceptor arrestin;
OS   Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8404;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=8536686; DOI=10.1111/j.1432-1033.1995.437_b.x;
RA   Abdulaeva G., Hargrave P.A., Smith W.C.;
RT   "The sequence of arrestins from rod and cone photoreceptors in the frogs
RT   Rana catesbeiana and Rana pipiens. Localization of gene transcripts by
RT   reverse-transcription polymerase chain reaction on isolated
RT   photoreceptors.";
RL   Eur. J. Biochem. 234:437-442(1995).
CC   -!- FUNCTION: Arrestin is one of the major proteins of the ros (retinal rod
CC       outer segments); it binds to photoactivated-phosphorylated rhodopsin,
CC       thereby apparently preventing the transducin-mediated activation of
CC       phosphodiesterase.
CC   -!- MISCELLANEOUS: Arrestin binds calcium.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; U30269; AAC59750.1; -; mRNA.
DR   EMBL; X92398; CAA63135.1; -; mRNA.
DR   PIR; S68173; S68173.
DR   AlphaFoldDB; P51479; -.
DR   SMR; P51479; -.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.640; -; 1.
DR   Gene3D; 2.60.40.840; -; 1.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR017864; Arrestin_CS.
DR   InterPro; IPR014753; Arrestin_N.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11792; PTHR11792; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Sensory transduction; Vision.
FT   CHAIN           1..396
FT                   /note="S-arrestin"
FT                   /id="PRO_0000205191"
SQ   SEQUENCE   396 AA;  44870 MW;  814B3F6D3F7D5939 CRC64;
     MSGDKKSRSV IYKKTSRDKA VSVYLGKRDY VDHIESVDPV DGVVFVDPDL LKGKKVYVTL
     TCAFRYGNED IDVIGLTFRK DLFFARIQVY PPVEDVKCLT KVQERLMKKL GNNAYPFVMA
     FPDYLPCSVS LQPAMSDVNK ACGVDFEIKA FSASNLEDRY HKKNSVRLLI RKIQYAPDQP
     GPTPRAETSW QFFMSDKPLH LTASLAKEVF YHGETITVAV TVTNNSEKTV KKISTSVEQT
     ANVVLYSSDF YTKTVAFDES DEKVSPKSTY KHTFTLLPLL AYNREKREIA LDGKLKHEDT
     NLASSTLLKE GIDRTVMGIL VDYKIKVTLT VSGLLGDMTS SEVSTELPFI LMHPKPDSGA
     KESEQEEDFV FEDFARDHLK DELQPEEKEE EEEDEK