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ARSA1_AQUAE
ID   ARSA1_AQUAE             Reviewed;         396 AA.
AC   O66908;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Putative arsenical pump-driving ATPase 1;
DE            EC=7.3.2.7;
DE   AltName: Full=Arsenical resistance ATPase 1;
DE   AltName: Full=Arsenite-translocating ATPase 1;
DE   AltName: Full=Arsenite-transporting ATPase 1;
GN   Name=arsA1; OrderedLocusNames=aq_682;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Anion-transporting ATPase. Catalyzes the extrusion of
CC       arsenite (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7;
CC   -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC06864.1; -; Genomic_DNA.
DR   PIR; H70359; H70359.
DR   RefSeq; NP_213468.1; NC_000918.1.
DR   RefSeq; WP_010880406.1; NC_000918.1.
DR   AlphaFoldDB; O66908; -.
DR   SMR; O66908; -.
DR   STRING; 224324.aq_682; -.
DR   EnsemblBacteria; AAC06864; AAC06864; aq_682.
DR   KEGG; aae:aq_682; -.
DR   PATRIC; fig|224324.8.peg.550; -.
DR   eggNOG; COG0003; Bacteria.
DR   HOGENOM; CLU_040761_1_0_0; -.
DR   InParanoid; O66908; -.
DR   OMA; TTVSCAY; -.
DR   OrthoDB; 1225869at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR040612; ArsA_HSP20-like.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10803; PTHR10803; 1.
DR   Pfam; PF02374; ArsA_ATPase; 1.
DR   Pfam; PF17886; ArsA_HSP20; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; ATP-binding; Nucleotide-binding; Reference proteome;
KW   Translocase.
FT   CHAIN           1..396
FT                   /note="Putative arsenical pump-driving ATPase 1"
FT                   /id="PRO_0000152260"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   396 AA;  45683 MW;  BBE56F87C959143D CRC64;
     MRIILFSGKG GVGKTTISAA TGYKLSQLGK KVIVVSLDPA HSLADSFDVP EEERRKAKGL
     PIKINENLEI QEIDIQEEIE RYWGEVYRFI ELLFHTTGLH EILADELAIL PGMEEITSLL
     YVNKYYREGN HDVLILDLPP TGESIRFVSM PTVMKWYMKK IFKTERLIMK VARPTVGRMT
     DVPLPDEEYF KALETFYERL KGVDEILINP DITSIRIVSN PEKMVLKESQ RAFLYFLLFG
     VNVDAVIVNK VIPEEVIQQE NCSFLEKWLN IQKKYVKEIE SYFSPVPVFK VPLLEEEVVG
     LERLEKLAQL IYGDEPPDKI FHKEIPYKIE QLDGKYVIRI KAPGVKKESI SLVKGEDEIV
     VRVGNFKAHV MLPRKLRNLE PERAKVEKDE ILIFMS
 
 
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